Application Study By Ultrasound Biomicroscopy In Patients With Glaucomatocyclitic Crisis

Objective: To observe features of the2-D image of glaucomatocyclit-iccrisis by ultrasound biomicroscopy during the treatment and quantitativelymeasure and compare the changes. To evaluate the clinical application valueand significance of UBM in different courses as well as treatment in follow-upof glaucomatocyclitic crisis. Make first study of pathogenesis.Methods: Fifteen eyes of fifteen patients with glaucomatocyclitic cr-isis were enrolled in this study. The mean age was35.33±9.84years ol-d. Their doctors’ visiting time was within1-10days. Unilateral involvement was noted in sevens men and eight women. Vision, IOP(intraocula-r pressure, IOP),anterior segment, fundus, gouioscopy, UBM, CMV-DNA (cytomegalovirus deoxynucleotide),HSV-DNA(herpes simplex virus deo-xynucleotide)examination were determined at first visiting time. Theywere given anti-glaucoma drug, corticosteroid and nonsteroidal anti-inflammatory eyedrops to control the inflammation. For example,a combinat-ion of Tobramycin dexamethasone eyedrop, Timolol0.5%, pranoprofeneyedrop, Meloxicam Tablets, were used. When the IOP was in normalrange,the patients were freed of using anti-glaucoma drug. Based on inflammation, corticosteroid was gradually descended untill stop treatment.UBM examinations were performed after treatment again. The examinations were performed for their in anterior chamber and its angle, posterior chamber, ciliary body, and anterior Vitreous body.The thickness of t-he ciliary body(T1,T2),ciliary process thickness(T),anterior chamber angl-e openness(AA),anterior chamber angle opening distance(AOD)were mea-sured. The fellow eyes of these cases were own control.15healthy a-dults were selected as the normal control group whose gender and agewere matching with glaucomatocyclitic crisis group.SPSS18.0statistic s- -dered significant.Results: At the first visiting time of the patients, the affect eyesT10.67±0.06, T20.49±0.06mm were all greater than the own control T10.62±0.05, T20.45±0.06mm(P <0.05). After treatment, T10.64±0.05、T20.45±0.07mm grew down than before (P <0.05). There was no statisticallysignificant difference between glaucomatocyclitic crisis group after treatmentand the own control group (P>0.05).At the first visiting time of the patients, T of the affect eyes1.46±0.10mm was larger than that of the own control1.43±0.09mm(P <0.05).When treatment was discontinuance, T1.40±0.11mm was smaller thanbefore (P<0.05). There was no statistically significant difference betweenglaucomatocyclitic crisis group after treatment and own control group(P>0.05).At the first visiting time of the patients, AA of the affecteyes48.15±8.55°compared with that of the own control group46.52±8.26°,there was no statistically significant difference (P>0.05). After treatment, theAA45.75±8.65°had less change than before. There was no statisticallysignificant difference between glaucomatocyclitic crisis and own controlgroup (P>0.05).At the first visiting time of the patients, AOD of the affect eyes0.41±0.06mm compared with that of the own control0.40±0.07mm, therewas no statistically significantly difference (P>0.05). After treatment, theanterior chamber angle opening distance (AOD)0.42±0.06mm had lesschange than before. There was no statistically significant difference betweenglaucomatocyclitic crisis and the own control group (P>0.05).The data was no statistically difference between unaffected eyes ofglaucomatocyclitic crisis group and the eyes of normal control group by usingtwo samples t-test.At the first visiting time of the patients, the IOP (intraocular pressure,IOP) of the affected eyes45.32±12.44mmHg was higher than that of unaffected eyes13.37±3.06mmHg. After treatment, it was reverse. The IOP ofthe affected eyes10.70±2.32mmHg was lower than that of unaffectedeyes12.84±2.68mmHg.The features of the2-D image of glaucomatocyclitic crisis by ultrasoundbiomicroscopy:1anterior inflammation;2larger ciliary;3part of ciliary cyst;4anterior vitreous opacity.The age and gender were no statistically difference betweenglaucomatocyclitic crisis group and normal control group by using twosamples t-test and Chi-square tests.Conclusion:1In the stage of glaucomatocyclitic crisis attack, the ciliary body ofaffect eyes were larger than normal.2In the stage of glaucomatocyclitic crisis attack, the anterior chamberangle openness and the anterior chamber angle opening distance had lessinfluence.3UBM can reveal diversify regularity of the ocular anterior segment withacute glaucomatocyclitic crisis before and treatment.4Auantitative measurement of UBM can offered important informationamong monitoring treatment effectiveness of glaucomatocyclitic crisis andchanges in different stages.