| Part1Left Ventricular Regional Cardiac Function in Healthy Youngand Middle-aged Chinese:Evaluation with256-slice ComputedTomographyObjective: To establish the normal range of left ventricular (LV)regional function in healthy young and middle-aged Chinese using256-sliceCT,and to explore certain regularity of left ventricular regional functionparameters of16segments.Methods:138cases underwent256-slice CT angiography and cardiacfunctional analysis.Dedicated software on the Extended Brilliance Workspace(Philips Medical Systems) was used to calculate end-systole wallthickness,end-diastole wall thickness,wall thickening%and wall motion foreach of16segments. Statistical analysis was performed.Results:1The normal range of left ventricular (LV) regional function parameters inhealthy young and middle-aged people was gotten with256-slice CT.2Based on the anatomy of left ventricular wall,16segments was divided intotwo parts: the left ventricular free wall and the interventricular septum.EDWTand WM increase gradually from the apex to the the base; ESWT was largestnear the papillary muscle, the second one was at the base, the smallest one wasat the apex; WT is largest at the papillary muscle, the smaller at the apex,smallest at the base. Left ventricular interventricular septum: EDWT andESWT and WM are largest at the papillary muscle, the smaller at the apex,smallest at the base; WT gradually decreases from the apex to the base. Thevalues of the free wall segments is larger than those of interventricular septum segments.3In circumferential direction: from anterior, antero-septal, infero-septal,inferior, posterior to lateral, EDWT, ESWT, WT%, WM tend to distribute inthe shape of "V" on the scattergram approximately.4In longitudinal directions: from the apex to the base, EDWT, ESWT, WT%and WM distribute as the shape of inverted "V" on the scattergramapproximately.Conclusion: establish the normal range of left ventricular (LV) regionalfunction parameters in healthy Young and middle-aged people by256-sliceCT,and the values of16segments has certain regularity.Part2The Correlation between Isolated Left Anterior DescendingCoronary Artery Stenosis and Left Ventricular Regional Function:Accessment with256-slice CTObjective: To explore the influence of isolated left anterior descendingartery(LAD) stenosis on left ventricular regional function using256-slice CTcoronary angiography and LV function analysis.Methods: Totally1584patients with256-slice CT coronary angiographyand LV regional function analysis were included for the retrospectivelyanalysis the last two years. Two radiologists who experienced in diagnosticcardiovascular imaging choose248cases of isolated left anterior descendingartery stenosis. These cases were divided into4groups according to theseverity of stenosis: LAD stenosis≤25%is ascribed to the group of normal,26%-50%to the group of mild stenosis,51%-75%to the group of moderatestenosis,LAD stenosis＞75%to the group of severe stenosis.Dedicatedsoftware on the Extended Brilliance Workspace (Philips Medical Systems)was used to quantify the value of of LV regional functional parametersautomatically,including: end-systole wall thickness(ESWT), end-diastole wallthickness(EDWT), wall thickening%(WT), wall motion(WM). All data wereanalyzed with statistical software.Results:1The comparison and correlation among groups of different stenosis of isolated LAD and EDWT, ESWT, WT,WM.EDWT: for segments of S1、S3、S14、S15, there is significant differentbetween the severe group and that of normal group (p=0.001,0.007,0.016,0.002<0.05，mild group (p=0.004,0.024,0.009,0.002<0.05). For segments ofS2、S7, severe group was different from those of normal group（p=0.009、0.000<0.05）,mild group （p=0.014,0.000<0.05） and moderate group（p=0.021,0.031<0.05）.For segment of S13,significant difference was foundbetween normal and mild group, severe group（p=0.005,0.009<0.05）and mildgroup（p=0.009,0.018<0.05）, while there was no obvious difference betweensevere and mild group（p=0.803）.There was positive correlation between thevalue of S1,S3,S8and severity of stenosis（p=0.034,0.032,0.026<0.05）(r=0.152,0.153,0.159). To S8, moderate group was different from that of normalgroup（p=0.005<0.05）,mild group （p=0.006<0.05） and severe group（p=0.045<0.05）for WT. Significant difference were detected for WT of S15between normal and mild group, severe group （p=0.013,0.012<0.05）andmild group （p=0.09,0.008<0.05）, while there was no difference betweensevere group and mild group（p=0.990>0.05）.There was negative correlationbetween the value of WT of S3、S15and severity of stenosis（p=0.005,0.015<0.05）(r=-0.199,-0.173). WM and ESWT: there was no differenceamong four groups, and no correlation with severity of stenosis2EDWT of S1, S2, S3, S7, S13, S14, S15increase from normal group tosevere group, while WT of S8、S15decrease with aggravation of stenosis.Conclusion: There were no significant difference of left ventricularregional functions in mild stenosis group compared with normalgroup.Whereas,between the moderate and severe group, EDWT and ESWT ofS1, S2, S3, S7, S13, S14, S15were different significantly. There was positivecorrelation between severity of stenosis and EDWT, while negative with WT... |
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