| Objective: 1. To study the difference on the ventricular function of hypertensive and normal human by Real-time three-dimensional echocardiography (RT-3DE), Quantitative tissue velocity imaging (QTVI).2. To study the correlation between the traditional two-dimensional echocardiography (2DE) and Real-time three-dimensional echocardiography (RT-3DE), Quantitative tissue velocity imaging (QTVI) when they evaluate the left ventricular function.3. To study the different effect of the ventricular diastolic function of hypertensive who are treated by integrated traditional Chinese and Western medicine or Western medicine only by Real-time three-dimensional echocardiography (RT-3DE), Doppler tissue imaging (DTI), Strain rate imaging (SRI) and Quantitative tissue velocity imaging (QTVI).Methods: 1.The study population is consisted of 30 hypertensive patients (15 men, 15 women) without other cardiac diseases and systemic disorders. All subjects were in sinus rhythm and showed no abnormalities on ECG. For all, grey-scale 2D echo images showed normal cardiac function on visual inspection. The hypertensives were randomly divided into A group. And 30 age-and gender-matched normal volunteers (control group, 15 men, 15 women).It was divided into B group.2. For data acquisition, four complete cardiac cycles were collected and stored in a cine-loop format. Data were acquired with the subjects at rest, lying in the left lateral supine position. General echocardiographic parameters were measured: end diastolic volume (EDV), end systolic volume (ESV), stroke volume(SV)and derived ejection fraction (EF) of the left ventricular; Blood pool pulsed Doppler recordings was obtained from the mitral valve inflow which were used to measure the following Doppler flow parameters: the peak velocity of E and A waves, the E/A ratio. 3.To measure the left ventricular mass (LVM), left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), troke volume (SV),ejection fraction (EF),peak filling rate (PFR), peak ejection rate (PER),regional end-diastolic volume (rEDV), regional end-eystolic volume (rESV), regional troke volume (rSV), regional ejection fraction (rEF),regional peak ejection rate (rPER),regional peak filling rate (rPFR) of the group A and B by real-time three-dimensional echocardiography (RT-3DE).4. To measure the Peak filling rat (PFR), Tissue move ahead duration 1(TMAD1), Tissue move ahead duration 2(TMAD2), Tissue move ahead duration midpt (TMAD Midpt) of the group A and B by Quantitative tissue velocity imaging (QTVI).5. Results are reported as means±standard deviations. Differences in continuous variables between 2 groups were assessed using the t-test, The Pearson correlation coefficient(r) was used to measure the strength of the association between the parameters.All data analysis was performed using statistical analysis software packages SPSS 17. Results: 1.There are difference on the Left ventricular mass, Left ventricular massindex, Peak filling rate and Peak ejection rate of the group A and B. (P<0.01).2. Part of 17 segments rSV, rEDV, rESV, rPER, rPFR and rEF were significantly different on the group A and B. (P< 0.05).3. PER, PFR, TMAD1, TMAD2, TMAD Midpt were significantly different on group A and B. (P<0.01).6. PFR acquired by RT-3DE had significantly negative relation with PFR and TMADM acquired by QTVI. (r1=0.570, P<0.01, r2=0.412, P<0.01).EF acquired by RT-3DE had significantly negative relation with EF acquired by QTVI. (r=0.871P<0.01). EF acquired by RT-3DE and QTVI had significantly negative relation with EF acquired by 2DE. (r1=0.899, P<0.01, r2=0.836, P<0.01).Conclusions: 1.There is a difference between the ventricular function with the hypertensions and normal human and they may clinical by Real-time three- dimensional echocardiography (RT-3DE) and Quantitative tissue velocity imaging (QTVI).2. There is a difference between the regional ventricular function with the hypertensions and normal human.RT-3DE provides a new method in assessing the regional left ventricular function. |
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