The Expression Level And Value Of CCL-18in The Serum Of The Patients With Chronic Obstructive Pulmonary Disease

BackgroundChronic obstructive pulmonary disease (COPD) is a common disease, frequently-occurring disease of respiratory system. It is a kind of lung disease which can prevent and treatment. It is due to the chronic bronchitis and emphysema. Limited airflow is not fully reversible and developing progressively. Research suggests the pathogenesis of COPD is related to cigarettes, smoke, waste gas and other harmful gases or particles of abnormal inflammation. According to statistics, COPD is the fourth death in the world in2000. It will maybe rise for the third by2020. And it will become the fifth of the economic burden in the world. In recent years, chronic obstructive pulmonary disease prevalence rate increased year by year, and the case of fatality rate is high. It can seriously affect the patient’s quality of life and work ability. It also can increase the economic burden of family and society. COPD has become an important public health problem.The pathogenesis of COPD has not been fully elucidated, and it has many kinds of pathological performance. At present, the markers can be used for the evaluation of chronic obstructive pulmonary disease (COPD) patients and the clinical curative effect is limited. Many studies have shown that inflammation is a central part of the COPD pathogenesis. A variety of cytokines, chemokines, inflammatory cells and adhesion molecules are involved in the occurrence and development of COPD. Some cytokines and chemokines may become a severity index of clinical evaluation of COPD, and play a very important role in the process of its onset. CC chemokine ligand-18(CCL-18) belongs to CC chemokines. CCL-18mRNA continued to express on a high level in the lung. Some studies have found that it is likely to be involved in the body’s initial immune response, but there is no domestic study in the role of COPD. Interleukin-6(IL-6) is a former inflammatory factor. It can promote and increase the development of local inflammation reaction and play an important role in the pathogenesis of COPD.Therefore, the exploring of CCL-18in COPD development process can understand the role in the inflammation process of the disease, and guide the clinical treatment.ObjectiveTo determinate the changes of CCL-18and IL-6level in the serum of patients with chronic obstructive pulmonary disease in acute aggravating period and after treatment, and compare with healthy crowd, measure it’s correlation with pulmonary function in patients. Study the clinical significance of ccl-18in the serum of patients with chronic obstructive pulmonary disease in the process of treatment. Judge patient’s illness severity and provide basis for guiding treatment.MethodsExtraction of30patients with chronic obstructive pulmonary disease in the aggravating period in the first affiliated hospital of Zhengzhou university between July2012and September2012.According to patients’ age, gender, choose30cases of clinic health checks for a control. Exsanguinate the venous blood of the patients with chronic obstructive pulmonary diseases and healthy controls in the morning and fasting state. Centrifugal enzyme-linked immunosorbent method after testing each CCL-18and IL-6levels of change in the serum, and evaluate its correlation with pulmonary function of these patients. ResultsThe levels of CCL-18and IL-6in the serum of the patients with chronic obstructive pulmonary disease in acute aggravating period before and after treatment are significantly increased than the levels in the health group. Difference was statistically significant (P<0.05)The levels of CCL-18and IL-6in the serum of the patients with chronic obstructive pulmonary disease in acute aggravating period after treatment are decreased obviously than the levels before treatment. Difference was statistically significant (P<0.05). CCL-18and IL-6in the serum is negatively correlated with FEV1percentage of expected values and FEV1/FVC numerical of lung function in the patients.ConclusionCCL-18may be involved in the inflammatory response of chronic obstructive pulmonary disease. Its detection is guiding significance to the judgment of patients with chronic obstructive pulmonary disease severity. It can be used as a judgment index in patients with COPD, and guide the clinical treatment of COPD.