Different Risk Factors For Lower Limb Vascular Lesions In Obesity And Non-obesity Diabetic Patients

Objective：To explore the related risk factors of lower limb vascular lesions in type2diabetes with and without obesity,and to prevent the occurrence and progress oflower limbs of vascular lesions targetedly.Method：1. The subjects:487diabetic patients are observed from theEndocrinology Department of our hospital from June2010to November2011.(No lower limb vascular lesions135, with the lower limbs vascularlesions352).2. Inclusion criteria:(1)The diagnosis of diabetes mellitus accorded withthe new diagnosis criteria of WHO in1999.(2)The diagnosis of the lower limbvascular lesions of diabetes mellitus depended on the color doppler ultrasoundexamination:<1>the thickening of artery intimal is equal or greater than1mm;<2> arteriosclerosis;<3> single or multiple atheromatous plaque;<4> stenosisor occlusion. Any kind of these4kinds of pathological changes is thought tohave lower limb vascular lesions.3. Study methods: The patients were divided into non-obesity group (BMI<25kg/m2) and obesity (BMI>25.0kg/m2) according to body mass index(BMI). The differences of general clinical data and biochemical indicators were compared between non-obesity and obesity group, such as the age,gender, the duration of disease, blood uric acid (BUA), fasting plasma glucose(FPG) and glycosylated hemoglobin (HbA1c), body mass index (BMI),systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride(TG), cholesterol (TC), high density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C). Relevant variability of lowerextremity vascular lesions of the non-obese and obese variables was analyzedby logistic regression analysis.4. Statistical methods:SPSS16.0statistical software is applied to analyzethe data.The measurement data of normal distribution and meetinghomogeneity of variance is expressed by mean±standard deviation,andindependent samples t test is applied to compare the mean of the twosamples.The measurement data of abnormal distribution is expressed bymedian(lower quartile,upper quartile),and independent samples rank sum test isapplied to compare them.After evaluate the main research factors,use whether ithas lower limbs vascular lesions as the dependent variable,the clinical andbiochemical characteristics as the independent variable to carry throughmultifactor logistic regression analysis.Result：1. In non-obesity subjects with the lower limbs vascular lesions hadsignificantly higher age,the duration,blood uric acid,fastingblood-glucose,glycated hemoglobin,body mass index when compared with nolower limb vascular lesions subjects(p<0.01), On the other hand,in obesity subjects with the lower limbs vascular lesions had significantly higher age,theduration,systolic blood pressure, cholesterin, low density lipoproteincholesterol, body mass index when compared with no lower limb vascularlesions subjects(p<0.01)。2. The Logistic regression suggested the related risk factors of the non-obesitysubjects were age, duration, smoking history, blood uric acid, fastingblood-glucose, body mass index，while the obesity subjects were age, gender,blood pressure, high-density lipoprotein cholesterol, low density lipoproteincholesterol,body mass index.Conclusion：The related risk factors of the non-obese group include age, duration,smoking history, blood uric acid, fasting blood-glucose, body mass index, andthe obese group include age, gender, blood pressure, high-density lipoproteincholesterol, low density lipoprotein cholesterol,body mass index, suggestingresearch for different approaches according to body mass index in T2DM withor without obesity is warranted．...