Intravenous Dexmedetomidine Pretreatment Suppresses Fentanyl-induced Cough

Purpose:To investigate whether intravenous dexmedetomidinepretreatment suppresses fentanyl-induced cough or not.Methods: One hundred and ninety patients, aged from18to65years,man or women, ASA Ⅰ～Ⅱ, undergoingvarious elective surgery, wereenrolled in this study. All patients were randomly assigned to one of threegroups which include control (C) group (n=63), dexmedetomidine0.2μg/kg (D1) group (n=63), dexmedetodine0.5μg/kg (D2) group (n=64).D1group, D2group were respectively administered intravenously0.2μg/kg and0.5μg/kg dexmedetodine diluted with saline in20ml and Cgroup were administered with20ml saline in10min. All groupssubsequently received a fentanyl (200μg for45-69kg and250μg for70-90kg) bolus in2seconds. We recorded the number of coughs of each groups for1min after fentanyl injection. Changes of the HR, MBP andOAA/S were recorded before and10min after DEX or saline injectionand1min after the injection of fentanyl.Result: The incidence of fentanyl-induced cough was significantlydecreased in D1group and D1group contrasted with C group (7.9%and4.7%vs.25.4%; P<0.05). There were no significant differences in theseverity and onset time of cough among three groups. The differencesbetween D1group and D2group on the incidence of cough did not haveand statistic meaning. In group D1, HR, SBP, DBP decreased in T1, T2and T0, but no significant difference; in group D2, T1, T2in the aboveindex compared with T0decreased significantly (P<0.05); at T0, nosignificant difference between the three groups hemodynamic indexes inT1and T2; in group D2, HR, SBP, DBP were significantly lower thanthose in C group, the difference was statistically significant (P<0.01),group D2HR in T1, T2time compared with the D1group decreasedsignificantly, the difference was statistically significant (P <0.01).Conclusion: Intravenous pretreatment with DEX0.2μg/kg and 0.5μg/kg can significantly suppress fentanyl-induced cough.