Study On Relationship Between Nutritional Situation Of Lodin And Thyroid Disease Of Two Thousands Children Aged4-6Years Old In Changchun City

Background：Iodine is an important raw material for human thyroid hormonesynthesis, amount of iodine intake is always endocrine workershypothyroidism with a focus of thyroid disease incidence and iodized saltintake too much closely related. China began implementation of universalsalt iodization regulations. In2001the who, the prevention and treatmentof iodine deficiency disorders Commission and the United NationsChildren’s fund, first proposed the dosage range and definition of humanenough iodine intake, more than adequate iodine intake and excessiveiodine intake. According to this standard, our country residents has beenmore than adequate iodine and excessive state since1997. Thyroiddisease incidence and iodized salt intake too much closely related, somescholars began to question USI. Epidemiological survey found indomestic iodine intake excessive induced increase of thyroid diseases.The iodine metabolism, abnormal intake influence on children withthyroid disease is very common health, serious intake, metabolic abnormalities and will affect the normal growth and development ofchildren.Objective:By using the method of investigation of Changchun City two districtand4~6years old children2000urinary iodine, thyroid function andthyroid ultrasound. Analysis and comparison of4~6years old childreniodine nutrition status and analysis of thyroid function and thyroid diseaserelated.Methods:a cross-sectional survey of Changchun City two district and4~6years old children2000urinary iodine, thyroid function and thyroidultrasound. Analysis and comparison of4~6years old children iodinenutrition status and analysis of thyroid function and thyroid diseaserelated.Result:1.The average value of urinary iodine of1male children was228.87μ g/L was significantly higher than girls in217.64μ g/L mean, P=0.0158;14.68%(148cases) boy urine iodine value was less than100μ g/L level(iodine intake), close to13.59%boys and girls;(137cases) urinary iodinevalue more than300μ g/L (excessive iodine intake)17.74%, significantlylower than girls, p=0.0275. No differences between urban and ruralchildren urinary iodine level. 2.Urinary iodine of children aged2.5with an average of232.55μg/L is higher than the4group of221.52μ g/L and6years old group,213.48μ g/L, P=0.0088; from4years to6years, with the increase of age,the proportion of children urinary iodine sufficient number increasesgradually, but the iodine deficiency and iodine excess children proportiongradually reduced, P=0.0091.3. with age increasing, the thyroid volume also increased, but thelevel of urinary iodine and thyroid volume were negatively correlated;4.girls in the mean value of FT3(4.86pmol/L) was significantlyhigher than that of boys (4.68pmol/L), p=0.0020; the boy FT4averagevalue (19.38pmol/L) was significantly higher than that of girls (17.35pmol/L), P <.0001; no gender difference in the TSH level; the FT3levelincreased gradually with the increase of age, P <.0001. But5childrenaged FT4and TSH level were significantly higher than those of4yearsold and6years old, P=0.000and0.034.5.The correlation coefficient of4~6years old children urinaryiodine level of children with FT3hormone levels were:0.625,0.609,0.585, both P <.0001, with significant difference; correlation coefficientand FT4hormone levels were:0.637,0.662,0.613, both P <.0001, withsignificant difference; correlation coefficient TSH hormone levels were:0.501,0.347,0.485, both P <.0001, with significant difference. The agegroup of children urinary iodine level was positively correlated with children’s thyroid hormone FT3, FT4. Negative correlation with thyroidhormone TSH.6.in2000children tested, hypothyroidism detection rate was4.5‰;subclinical hypothyroidism detection rate was9.5‰; hyperthyroidismdetection rate was4‰; subclinical hyperthyroidism detection rate was11‰; all kinds of abnormal thyroid function detection rate was29‰.7.girls hypothyroidism detection rate (7.06‰) and subclinicalhypothyroidism (15.12‰) was significantly higher than that of boys(1.98‰and3.97‰), P=0.09and0.01.8. Girls hyperthyroidism (7.06‰) and subclinical hyperthyroidism(17.14‰) detection rate is higher than that of boys (0.99‰and4.96‰),P=0.032and0.009. All kinds of abnormal thyroid function detection ratewas56.45‰and11.90‰girls, was significantly higher than that ofboys, P=0.000.9. Children of various thyroid function in abnormal detection rate(7.08‰) was significantly higher than that of the township (3.47‰),P=0.023.10. Hypothyroidism and subclinical hypothyroidism occurred in theurine iodine value is lower than100μ g/L group, the positive rate was22.15‰and44.30‰, significantly higher than100μ g/L, P=0.000;11hyperthyroidism and subclinical hyperthyroidism mainly Yu Dian (excessive intake of iodine value of300~500μ g/L) children, thedetection rate was15.66‰, significantly higher than300μ g/L, P=0.000.11.In the subjects of2000children, diagnosed patients with variousthyroid diseases in22cases, the total positive rate was11‰, of whichgirls thyroid disease detection rate was15.12‰, almost all girls in thedetection of thyroid disease rates are higher than those of boys. In thesecases, nodular goiter prevalence is higher, followed by Graves’ diseaseand thyroid single nodule. The same thyroid cancer also occurs inchildren.12. Urinary iodine level is lower than100μ g/L and urinary iodinelevel higher than300μ g/L in children with thyroid disease detection rateis higher than that of urinary iodine levels in100～300μ g/L thechildren, P=0.000.13.21.43%hypothyroidism and sht children and16.67%childrenwith hyperthyroidism and subclinical hyperthyroidism is qualitative inchildren with thyroid disease; thyroid function in normal children only0.57%detectable organic thyroid disease, hypothyroidism andhyperthyroidism were significantly lower than those of children, P <0.05.Conclusion:1.There are gender differences in urinary iodine level of children, themale is higher than female. 2. with the increase of age, iodine deficiency and iodine excessnumber gradually decreased the proportion of children.3.girls FT3value is higher than the boy; the boy FT4value is higherthan the girls; no gender difference in children with TSH.4. children urinary iodine level associated with childhood thyroidhormone FT3and FT4concentrations, and negatively correlated with thelevel of TSH.5. of the total detection rate of abnormal thyroid function there is agender difference in urban and rural areas, girls than boys, urban area ishigher than the villages and towns.6. children with thyroid function and urinary iodine value,hypothyroidism occurred in the iodine intake of children; hyperthyroidismmainly Yu Dian excessive intake of children.7. children also suffer from various thyroid diseases; associated withthese diseases and iodine intake level.