| Objective(1) Apply the concept of "stopping the progression of disease" in "preventive treatment of disease " to conduct intervention to patients with diabetic peripheral neuropathy. We conducted the research from theory and clinic aspect to improve the symptom and sign of DPN patients, to prevent the development of diabetic peripheral neuropathy and improve patients’quality of life.Methods97diabetes patients with peripheral neuropathy were randomly divided into experimental group (50cases) and control group (47cases). Control group was applied with basic intervention, which is diabetes "five carriages" management includes a control diet, regular exercise, the blood glucose and lipid regulating drugs, diabetes knowledge education, monitoring of blood glucose, and neurotrophic drugs orally (Methycobal). Experimental group was applied with "preventive treatment of disease" intervention in addition to basic intervention: emotional adjustment, massage, foot bath and diet with Chinese medicine, Bi’s exercise and foot care. After6consecutive months’ intervention, we compared the clinical curative effect and quality of life between two groups by observing index changes of the fasting blood glucose (FBG),2hour postprandial blood glucose (P2hBG), glycosylated hemoglobin (HbA1c), glycerin three greases (TG), total cholesterol (TC), symptoms score of foot and neural electrophysiological. We also used the survival of specific diabetes table (DSQL) to evaluate the life quality of patients.Results1. General information:there were no significant difference of gender, age, course of disease, weight, occupation, cultural degree and the genetic history between intervention and control groups (P>0.05). The two groups were comparable.2. Biochemical markers of glucose metabolism:(1) before intervention, there were no significant difference of FBG, P2hBG, HbAlc, TG and TC between experimental and control groups (P>0.05). The two groups were comparable.(2) for both groups, FBG, P2hBG and HbA1c were decreased to normal after intervention, and there were significant difference within groups (P<0.001); TG and TC of the experimental group intervention were not decreased to normal, but there was significant different within the group (P<0.001); TG of control group was not decreased to normal after intervention, but there was significant difference within the group (P<0.001); TC of control group was not decreased to normal after intervention and there was no significant different within the group (P>0.05).(3) FBG, P2hBG, HbAlc, TG and TC of both groups were decreased, and there was no significant different within groups (P>0.05).3. The clinical symptom score of foot:(1)there was no significant difference between intervention and control group before intervention (P>0.05).(2) after intervention, there was significant difference between two groups (P<0.001), which indicated the experimental group was better than the control group.(3) there was significant difference before and after intervention in intervention groups (P<0.001). the foot clinical symptom score decreased to below4points after intervention.(4) there was no significant difference before and after intervention in control groups (P>0.05).4. Common peroneal nerve conduction velocity:(1) there was no significant difference between experimental and control group before intervention (P>0.05).(2) There was significant difference of common peroneal nerve conduction velocity before and after intervention in experimental groups (P<0.001).5. Evaluation of the quality of life:(1) there was no significant difference of QOL score between experimental and control group before intervention (P>0.05).(2) there were significant difference of the scores of physiological function, psychological/mental dimension, treatment dimension within the experimental group (P<0.001); the score of social dimension has decreased after intervention, but there was no significant difference within the groups (P>0.05); there was significant differences of QOL score before and after intervention in experimental group (P<0.001).the results indicator "preventive treatment of disease" treatment has effect to improve the overall QOL of DPN patients.ConclusionDiabetic peripheral neuropathy required early prevention and comprehensive intervention. Our research conducted intervention to patients with diabetic peripheral neuropathy using the concept of "stopping the progression of disease" in "preventive treatment of disease ", the results show:(1) significantly modulate fasting blood glucose, postprandial two hour blood glucose, glycosylated hemoglobin and blood lipid levels of patients with DPN (2) improve the foot clinical symptoms of the patients with DPN.(3) Significantly improve the peroneal nerve conduction velocity of patients with DPN.(4) Significantly improve QOL of patients with DPN. This study suggests that "preventive treatment of disease" intervention has effect on the occurrence and development of diabetic peripheral neuropathy patients, and could improve the life quality of patients. |
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