The Expression Level And Clinical Significance OD Adiponectin And Adiponectin Receptor In The Patients With Gastric Cancer

Backgrouds Adiponectin, derived mainly from adipocyte, is present abundantly incirculating blood. It has been proved that adiponectin was closely associated with cancerespecially the obesity-related reproductive and digestive systems cancer. In this study, wedetermined the plasma levels of adiponectin in gastric cancer and healthy controlsrespectively, detected the expression of adiponectin receptor1and receptor2in theadipose tissue, investigated the relationship between gastric cancer and adiponectin andadiponectin receptor, thus to find out some evidences for early diagnosis and treatment ofgastric cancer.Methods First we selected randomly62patients who were diagnosed as gastric cancer atthe Affiliated Hospital of Taishan Medical College from February2009to February2011and31healthy controls. The concentration of adiponectin in two groups was detectedusing a specific ELISA assay, the expression of adiponectin receptor1and receptor2wasdetected using Polymerase Chain Reaction and Western blot, we also analyzed whetherthere have some difference in the expression between these two groups.Results The mean adiponectin levels in gastric cancer patients and healthy controls were9.7±5.2ng/mL and13.9±8.5ng/mL respectively, the plasma adiponectin concentration ofgastric cancer patients was significantly lower than the healthy controls, we found that thetissue level of adiponectin was much lower in cancer patients than in the healthy controlstoo. Meanwhile, the more serious of the patients, the lower of the adiponectin level in thetissue, it has a negative relationship with the Dukes’ classifations.We also found that there were both the expression of adiponectin receptor1and receptor2in neighboring noncancer tissues samples and gastric cancer tissues samples. Theexpression of receptor1was higher in gastric cancer patients than healthy controls, but theexpression of receptor2was unchanged. The regression analysis showed thathypoadiponectinemia may be a new risk factor for gastric cancer. Conclusion Our results showed that lower plasma levels of adiponectin were associatedclosely with gastric cancer. Meanwhile, the levels of adiponectin were negatively related tothe Dukes’ classifations of gastric cancer. There were both the expression of adiponectinreceptor1and receptor2in adipose tissues samples, but only the expression of receptor1was increased.Significance Our study investigated that both the adiponectin and adiponetin receptorplayed a key role in the progress of gastric cancer, the hypoadiponectinemia may be a newrisk factor for gastric cancer. Detection the levels of adiponectin and adiponectin receptorwill give us new methods and ideas for gastric cancer prevention, diagnosis and treatment.