Analysis Of The Clinical Factors Related To Recurrence Of Depression

BackgroundThe etiology of depression remains unknown, the clinical efficacy is still not very ideal. Depressive relapse more aggravate the pain of the patient, to prevent the recurrence of depression is the key to treatment of depression. It has been proved that depression is associated with many biological and psychosocial factors, some factors associated with onset, while other factors constitute the relapse mechanism. The factors which constitute a depression relapse mechanism research.ObjectiveThis study proposed by recurrent depression clinical characteristics, psychological characteristics evaluation and treatment of factors related to the comprehensive analysis, and screened and depression relapse relevant risk factors, this paper discusses the psychological and physiological mechanism of the depression relapse, the standardization of the treatment for depression, prevent recurrence and theoretical basis for strategy.MethodsSequential acquisition in January2011in January2012, a doctor in zhengzhou university first day in hospital and clinic affiliated hospital of repeated attacks of105patients with depression, into the standards include:(1) depression recurrence rate quartile (twice) depression.(2) comply with the mental disease classification scheme and diagnosis standard fourth edition (DSM-IV) diagnosis standard and emotional disorders depressive episodes diagnostic criteria.(3) to rule out duplex obstacles family history and manic episodes of the history of the patients.(4) the age16-60.(5) no serious body disease history.6subjects informed consent.Series "depression relapse questionnaire". Questionnaire content mainly includes:age, marriage, gender, educational level, family history, recurrence season, medication compliance, medication types and measuring, treatment, efficacy and break social function and recurrence, economic conditions and family support system psychological characteristics. The interview, hospital outpatient follow-up phone follow-up, the way of the combination of the fill in item by item, added complete return information. Questionnaire survey by the group members are complete. Data processing unified into the computer and software with SPSS17.0data analysis and arrange, statistical methods the x2inspection, logistic regression analysis related analysis of inspection standard a=0.05.Results(1)The patient complained of frequency in order:a bad mood (59.3%), dizziness (58.1%), difficulty falling asleep (54.3%), home (50.8%), poor appetite (42.3%), limb weakness (45.4%), dizziness (38.7%), frequency (38.7%), headache (35.5%), chest pain (32.3%), other (28.3%).(2)The DSM-Ⅳ reference axis I disorder clinical guide to the use of timing check (Study Edition)(Structured clinical interview for DSM-IV axis I disorders Research version) is a psychiatric examination, the main symptom frequency in turn:the depression (95.3%), sleep disorders (82.4%), loss of interest (79.1%), lack of energy (59.5%), activity reduce (49.8%), slow (42.3%), weight change (39.3%), pessimistic self-blame(34.6%), a Dutch act perception or behavior (28.6%).(3)The first psychiatric hospital was selected as follows:that is why frequency of somatic diseases accounted for60%, stigma accounted for24.4%, their attitude in4cases accounted for8.89%,2cases were not easily accounted for4.5%, the other2.2%.(4)The effect of drug treatment compliance factors frequency were:perceived was stopped in40cases, because of side effects of drug withdrawal in19cases,16cases of family supporters, due to study, work, get married and have children stopped in11cases, with other methods of treatment in3cases, poor economic ability in2cases.(5)There were high relapse group and low recurrence group sex, premorbid character and tendency, culture level and found:premorbid personality and tendency, culture degree (P<0.05), and gender (P>0.05).(6)1compare high relapse group and low relapse groups with and without family history of psychosis, negative life events, medication compliance, whether the first specialist treatment, treatment, medication time, seasonal factors found:with and without family history of psychosis, negative life events, medication compliance, whether the first specialist treatment, treatment, medication maintenance time (P<0.05), and seasonal factors (P>0.05).(7)He compares high relapse group and low recurrence group economic condition, social support, interest found:and economic conditions, social support, interest hobby related (P<0.05).(8)The multivariate logistic regression analysis revealed by screening variables into regression model variables were premorbid personality, cultural level, family history, economic conditions, medication maintenance time, medication compliance, negative life events, hobbies8factors were the main risk factors for the recurrence of depression. A multivariate logistic regression analysis showed:the economic situation, medication to maintain the time, medication compliance, no negative life events, hobby is the prevention of recurrence of depression of protective factors. While the character before disease, education, family history is the major risk factors for recurrence of depression.Conclusion(1)The use of maintenance time, medication compliance, economic conditions, life events, hobbies5depression factor was repeated recurrence of protective factors and risk factors.(2)The premorbid personality, education, family history and depression relapse is negatively related to depression, are important risk factors of recurrence. (3) The influence of family history of depression recurrence risk factor occupies first place.