| Objective:Insulin-like growth factor (IGF) is the body a kind of important growth factor, it to organize a cell proliferation and differentiation of and the body growth and the occurrence of cancer have an important regulatory role. Tumor markers in cancerous cells are generated by the process. It to cancer diagnosis, treatment, and prognosis observation has definite clinical significance. Clinical diagnosis of type2diabetes mellitus (T2DM) of patients exists beta cell function exhaustion, especially in older patients with type2diabetes ss-cell function failure is more apparent, this helps exogenous added insulin is used in old age more common type2diabetes treatment. Clinical for the elderly in the treatment of type2diabetes was orally, but also uses the insulin added scheme. Two kinds of different treatments and tumors have related? And IGF-1, IGF-2have the expression of contact at present there is no report. This study investigated childhood type2diabetes different treatment and medical crowd and normal controls the expression of IGF cancer group and tumor markers of change. Elderly patients with type2diabetes compared with unique treatments to control blood sugar and cell proliferation or tumor of the relationship. For clinical older adults with diabetes treatment for an empirical basis.Methods:In situate provincial people’s, hospital medical normal2010-2011people35patients, hospitalized patients with diabetes60cases and patients with tumor35patients as the research object. According to the research object is divided into four groups: Group A physical examination for routine control group35patients. Group B for type2diabetes oral drug group30cases. Group C for type2diabetes insulin treatment group (>1year, dose>28IU/day)30cases. Group D for tumor group (pathology basis)35patients. Separately on the height, weight, blood fat and blood sugar, fasting insulin, fasting c-peptide, T cells subsets and tumor markers, insulin-like growth factor-1(IGF-1), insulin-like growth factor-2(IGF-2) index for testing. The steady-state model and calculation of insulin resistance index (homa-ir), beta cell function index (HBCI), insulin sensitivity refers to (IAI). The analysis of variance for comparison between four groups the clinical indicator; Is likely to affect the insulin resistance of various factors on logistic regression analysis; IGF and correlation analysis between tumor markers. Analysis of the use of insulin elderly patients with type2diabetes each index and the change in the other three groups. Statistical analysis SPSS16.0packages to P<0.05for with a statistical significance.Results:This study participant included130patients, with an average age of70.3+/-9.18years old, four groups of age, gender, height no difference.1) medically normal control group weight, waist circumference, WHR diabetes drug group and the mean lower than diabetes insulin group P<0.05statistically significant. And diabetes mellitus insulin group and the drug group of body weight, between BMI, hip circumference is P>0.05duration was not statistically different.2) diabetes insulin group TC, TG mean higher than the other three groups and and medical normal controls and tumor group P<0.05statistically significant.3) Medical normal control group FPG, FINS, homa-ir mean less than the other three groups P<0.05statistically significant. And diabetes mellitus in four groups of insulin group homa-ir highest, IAI, c-peptide minimum.4) between four groups CD3+, CD4+, CD4+/CD8+no difference.5) tumor group AFP, CEA, CA153mean higher than the other three groups and P<0.05statistically significant. CA125, CA199and insulin group, is P>0.05duration was not statistically different.6) Medical normal control group IGF-1, IGF-2mean lower than with the other three groups P<0.05statistically significant, and diabetes mellitus insulin group IGF-1, IGF-2levels in four groups, including the highest igf-ii,1and tumor group P<0.05statistically significant.7) influence of insulin resistance of risk factors such as gender, age, duration, family history, BMI and waist, hip circumference, WHR, TC and TG of logistic regression showed that BMI, waist circumference is an important risk factors for insulin resistance.8) in IGF-1, IGF-2tumor markers and the relevant analysis found no correlation between the two.Conclusions:1) this study found older type2diabetes and cancer susceptibility to many of the tumor coexist risk factors such as age, obesity, high blood glucose, insulin resistance, high insulin hematic disease, insulin-like growth factor (IGF), the immune system disorders, etc.2) diabetes and cancer group crowd are tumor marker of increased two groups of comparisons to tumor group particularly increased.3) old type2diabetes insulin therapy and oral drug group there are IGF-1, IGF-2express a normal control group increased, two groups of control insulin group higher, hint may have cell proliferation expression of the increase.4) IGF-1, IGF-2abnormal expression in diabetic patients with tumor relationship to it is still not clear, use insulin hypoglycemic therapy of long-term safety needs to be further observation and research. |
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