Initial Research On The Relationship Between Rs2046210Gene Polymorphisms And Risk Of Breast Cancer

Objective:To investigate the association of a single nucleotide polymorphism (SNP), rs2046210of the peripheral region of the estrogen receptor1gene (ERS1) with women breast cancerMethods:Genomic DNA from255individuals of Guizhou women including114tissue slices of diagnosis of breast cancer patients and141healthy controls’peripheral blood was analyzed for the SNP rs2046210of the ESR1gene. SNP rs2046210was genotyped by polymerase chain reaction. A Chi-square test was used to determine the association of SNP with breast cancer.Results:The Hardy-Weinberg balance testing result showed, rs2046210genotype in healthy controls and breast cancer cluster distributions were consistent with Hardy-Weinberg equilibrium (x2value2.78and2.95respectively, v=1, P>0.05), showed that the research object had group representation. The frequency of C or T allele was56.60%or43.40%, respectively in breast cancer patients, while61.70%or38.30%in healthy controls. There was no significant difference between these two groups (P>0.05). The frequencies of genotypes CC, CT and TT of SNP rs20462101were35.96%22.81%and41.22%in breast cancer, which were different from that in controls35.75%、11.35%and53.90%respectively (P<0.05). Further comparisons revealed, genotype CC/TT in the two group distribution was of no difference (P>0.05), the relative risk ratio OR was1.94(0.92-4.1, CI95%); genotype CC/TC in the two group distribution was of no difference also (P<0.05), relative risk ratio was0.74(0.43-1.28, OR CI is95%), while the genotype TT/TC in the two group distribution had significant difference (P<0.05).Conclusion:rs2046210polymorphism has a potential to be a susceptibility factor for women breast cancer, while rs2046210TT genotype may increase an individual’s risk of breast cancer, and the CC genotype increment may reduce the risk of breast cancer.