The Expermental Study For Brain Collaterals ShuNing Capsule Of Vasculal Dementia

Objective:To validate the curative effect of Brain Collaterals ShuNing Capsule to vascular dementia by zoopery, at the same time try to understand the pathogenesis of vascular dementia.Methods:Using classic animal models to detect these dysmnesia animal models’ escape latency and errorcounts by making memory getting obstacles, memory consolidating obstacles and memory representation. Adopting bilateral cervical arteries ligation on rats to make the animal model of cerebral ischemia and reperfusion; as for the other one animal model, giving epinephrine before surgery; respectively filling rats’stomach with liquid medicine of Brain Collaterals ShuNing Capsule as2.66、1.33、0.67g/kg for a month. Then detecting the purity of Ach, AchE, GABA, Glu, Gly, Asp in hippocampus;5-HT, NE, DA in pallium and ET, TXB2,6-Keto-PGF1α, CGRP in serum of rats.Results:Brain Collaterals ShuNing Capsule can reduce the errorcounts and prolong the escape latency.When the Brain Collaterals ShuNing Capsule was given cerebral ischemia and reperfusion vascular dementia rats as2.66g/kg, it could obviously shorten the latentperiod and reduce the errorcounts in platform experiment; As for cerebral ischemia and reperfusion vascular dementia rats of Qi stagnancy and blood stasis syndrome,the errorcounts also could be clearly decreased when the Brain Collaterals ShuNing Capsule dosage is on2.66,1.33or0.67g/kg. Brain Collaterals ShuNing Capsule have increased the purity of Ach, GABA, Glu, Gly, Asp in hippocampus and5-HT, NE, DA in pallium and lowered the activity of AchE; besides, the Pills had significantly lowered ET, TXB2,6-Keto-PGF1a, CGRP in serum of rats.Conclusions:Brain Collaterals ShuNing Capsule could preferably play the Role to treat dementia on account of its effect. The mechanism is probabely relevant to the purity of Ach in hippocampus, lowering the activity of AchE; to adjust the brain neurotransmitters and vascular active material; to improve Blood rheology and so on.Brain Collaterals ShuNing Capsule has definite ability to ameliorate dysmnesia.