Part Of Shenyang Liver Biopsy Pathological Stage S3and S4Were Retrospectively Analyzed

Object：TO study the relationships among pathological and Diagnosis、Antiviraltreatment time in the patients with chronic hepatitis，in order to investigate the relationbetween the degree of fibrosis and clinical indexes.Methods：TO analyze the clinical data of292cases of liver biopsy in chronicHBV infection with pathologic stage S3S4，We compare the relationship betweendifferent age、course of disease, HBVDNA level、other related factors and thepathological diagnosis。Results：In292patients，pathological diagnosis of S3was140(47.9%) cases，the period of S4was152(52.1%) cases。 According to the comparison of differentage stratification﹤40years old,the percentage of S3phase is higher than of S4.≥40years old,the percentage of S3phase is lower than of S4.According to thecomparison of different ALT layers,in the S4period,the lever of ALT in1-2times thenormalvalues of the groups with the highest proportions.But in the S3period,the leverof ALT above1.0times the normalvalues of the groups with the highestproportions.Further multivariate analysis showed：course of disease，age,history ofdrinking， the layered ALT， HBVDNA levels and color。 Doppler ultrasoundexamination of liver surface is smooth and is consistent with independent risk factorsof pathological diagnosis。Conclusion：1. Course of disease above5years old and ALT level between1.0~2.0ULN and greater，change the ALT level of significance。2.For theassessmentof liver fibrosis treatment before the multi-factor analysis,not only on the basis of ALTlevel.