| Background：Nowadays diabetes mellitus is the most common endocrine systemdisease in the clinical work, which is a kind of metabolic disease thatdue to lack of insulin and (or) insulin biological function disorder andcauses a variety of acute or chronic complications. Since the30soverseas research reported that diabetes mellitus may lead to mineraland bone disorder, the phenomenon has been confirmed by more andmore research reports. It can be said that diabetic osteoporosis hasbecame a chronic complication of diabetes mellitus, which not onlyinfluences the patients’ quality of daily life, but also threatens people’shealth and safety. According to the current study, the relationshipbetween type1diabetes and osteoporosis has been quite clear, but theinfluence of type2diabetes on bone mineral density is still controversial,and most reports consider that there is a close correlation between type2diabetes mellitus with osteoporosis. According to previous studiesreports, the cause of abnormal bone metabolism in type2diabetes mainmay be related to long-term high blood glucose, insulin deficiency, theaccumulation of advanced glycation end products as well as the metabolic disturbance of calcium and phosphorus. It is analysed thatbone mineral density of type2diabetes is closely correlated with isletbeta cell function. The fluctuation of insulin levels in patients with type2diabetes may be the important reason for the inconsistent results ofbone mineral density measurement.Objective:The purpose of this study is to observe the difference of serumc-peptide levels, HOMA-HBCI, HOMA-IR, osteocalcin, etc betweengroup DOP and group NDOP. Through the comparison of the results,observing the influence of islet beta cell function on bone mineraldensity, discussing the correlation between the development of type2diabetic osteoporosis and c-peptide level, providing the basis for theearly prediction and treatment of type2diabetic osteoporosis.Method:Choicing90cases who were hospital diagnosed as patients with type2diabetes, and meet the sift criteria. All patients were measured bone mineral density of femoral neck，and divided into group DOP and group NDOP. As follows:1.Recording two groups ofpatients’ general data.2.Sampling two groupsof patients’ blood respectively, determinating of blood glucose, blood lipids, liver function,renal function， glycated hemoglobin index, and determinating fast ing insulin, fastingc-peptide, postprandial2hour c-peptide, osteocalcin. Calculating HOMA-IR and HOMA-HBCI. The observationsx±s and between the two groups are compared by t test. The comparisonof gender uses X2test. All the data use statistical software SPSS21.0statistical analysis. P<0.05statistically significant. Using mult-variable linear return analysis to discussthe correlation among bone mineral density and fasting c-peptide, postprandial2hour c-peptide，osteocalcin，HOMA-IR as well as HOMA-HBCI.Results：There are no obvious difference for age, sex, duration of diabetes, and BMI, HbA1C, as well as all the biochemical indicators of the two groups, with no statistically significant (P>0.05), two groups can be compared. Fasting c-peptide, Postprandial2h c-peptide,HOMA-HBCI, osteocalcin of Group DOP are lower than those ofgroup NDOP, with statistical significance(P<0.01), HOMA-IR of the two groups patients have no significant difference (P>0.05).Theresults of mult-variable linear return analysis show that there arepositively correlations among Fc-p,P2hc-p,HOMA-HBCI,osteocalcinand bone mineral density; and no significant relation between HOMA-IR and bone mineral density. Conclusions:Bone mineral density in patients with type2diabetes is closelylinked with islet beta cell function. Insulin affect bone metabolismthrough various channels. The lack of insulin disrupt the balancebetween bone resorption and bone formation, lead to the normal boneconversion disorder, damage the stability of bone mass. |
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