Study On Induction Dose Of Propofol Acute Hypervolemic Hamodltutlon

Purpose:To study the effects of acute hypervolemic hemodilution on propofolanesthesia induction dose.Methods:40cases underwent Department of general surgery under generalanesthesia in patients undergoing resection of colorectal cancer, were randomlydivided into control group (group A) and acute hypervolemic hemodilutiongroup (group B), each group of20cases. ASA I-II, age30to60years of age,body weight50~80kg, hypertension, anemia, liver and kidney dysfunction,coagulation abnormalities, hypoproteinemia, endocrine system disease, heartand lung function were not excluded experiment. And the conventionalcontinuous monitoring of the electrocardiogram (ECG), non-invasive arterialpressure (NIBP), pulse oxygen saturation (SpO2). The radial artery punctureunder local anesthesia monitoring invasive arterial pressure (ABP) under localanesthesia, the right internal jugular vein catheterization monitoring centralvenous pressure (CVP). Induction of A group before the conventional input8ml/kg normal saline, B group of transjugular rapid infusion of6%hydroxyethyl starch (130/0.4),15ml/kg,30min after transfusion, completedafter induction of general anesthesia. The two groups were no premedication. Induction of medication of midazolam0.05mg/kg, fentanyl3UG/kg,0.15mg/kg of cisatracurium, wait1to2minutes to make full use of propofol effectmore drugs again, propofol dose based on bispectral index (BIS) monitoringnumerical adjustment.50as the target value, with intravenous injection ofpropofol pump, speed of100ml/h, BIS value was observed, when the BIS valueis reduced to45~50, the stop input of propofol, and record the implantationdose, according to patient weight calculated per kg body weight dose. Recordedbefore AHH T0, AHH T1, before giving propofol T2, administered propofolBIS was stable in45~50T3.Recorded at each time point, the systolic bloodpressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP),central venous pressure (CVP) and heart rate (the changes of HR).Results: No statistically significant differences between the two groups ingender, age, height, weight (P>0.05). Dilution group (group B) and propofolinduction dose per kilogram of body weight than the control group (group A)decreased significantly, there was statistically significant (P <0.01). T0twogroups of patients with MAP, CVP, HR had no significant difference; T1MAP,CVP of patients in group B were high in patients with A group, there wasstatistically significant difference (P<0.05), HR two group was not obvious; T2,A, B two groups of patients with MAP were decreased, A group decreasedmore; T3, A group than in B group MAP decreased significantly in group B,HR, MAP does not fluctuate greatly, CVP has increased but still within thenormal range, higher than that in the A group (P <0.05). Conclusion: The patients with acute hypervolemic hemodilution in the use ofpropofol during induction of general anesthesia dose significantly reduced，andthe blood flow in the course of induction is safe and stable.