| Background Being one of the most serious diseases all around the world, ischemic cerebrovascular disease has become a disease with the second mortality in China and a gradually younger onset age. The ischemic cerebrovascular disease has a seriously harm to the health of human beings and the quality of life, which brings heavy load not only to the society but also to the families. A vascular endothelial progenitor cell is a kind of precursor cell which could differentiate into mature endothelial cell in vitro and in vivo. Atherosclerosis is the main dangerous factor to ischemic stroke, and the main basic pathology is the arteriostenosis and thrombopoiesis caused by the new intima hyperplasia and endothelial dysfunction after vascular injury. Apoptosis induce plaque from stable plaque into a vulnerable plaque, leading to the occurrence of stroke events. Endothelial progenitor cells are precursor cells differentiate into mature endothelial cells in vitro and in vivo. Under the stimulation of the physiological factors or pathological factors, once being released into the blood circulation, EPCs will reside in the vascular injury sites and participate in the regeneration and repair process of vascular endothelium. Meanwhile, EPCs will promote the ischemia tissue angiogenesis and relieve the intimal thickening degree during vessel repair process. The reflections of EPCs to the endothelium and vessel regeneration capacity, as well as the plaque burden of the atherosclerosis, have already become new independent hazards to the atherosclerosis diseases. And the peripheral blood EPCs quantity, being the evaluation index for the vessel functions, has independent predictive value for stoke events.Objective To have new trains of thought and rationales for the preventive treatment of clinical ischemic stroke and to provide new basis for the treatment of the ischemic cerebrovascular diseases, this study surveys the correlation of the EPCs quantity variation in the peripheral blood with the TOAST criteria and the plaque properties through the detection of the EPCs quantity in the peripheral blood.Method Divide the patients into case group and matched group. In the case group, are62acute ischemic stoke diagnosed patients. Apply the carotid ultrasound and other image studies such as CT to group the case group according to the TOAST criteria and the plaque properties. In the matched group are17healthy people who came to the hospital for physical examination at the same time with those diagnosed patients.Use the Flow Cytometer to detect the endothelial progenitor cells quantity in the peripheral blood, and then have a SPSS statistical analysis of the observed endothelial progenitor cells quantity. Observe the correlation between different TOAST criteria and different plaque properties respectively.Result Divide different TOAST criteria into five groups:ALL group with24patients, SAA group with22patients, CE group with7patients, SOE group with3patients, and SUE group with6patients. The difference between the different endothelial progenitor calls quantities in different TOAST criteria has statistical significance (F=5.063, P=0.001), and the difference between the mean quantity of every group also has statistical significance. Divide the different plaque properties into two groups:the vulnerable plaque group with18patients, and the non-vulnerable plaque group with17patients. The difference of endothelial progenitor cells quantities between these two groups also has statistical significance (t=2.854, P=0.007)Conclusion The EPCs quantity in the peripheral blood will drop down in acute ischemic stroke, and the quantity shows some correlation with the carotid antherosclerotic plaque properties, and the TOAST criterion such as LAA, SAO and so on. These indicate the influence of vulnerable plaque case and different pathogenesis on prognostic. |
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