Comparative Analysis Of Coronary Artery Disease Assessed By Dual-source CT Coronary Angiography Between Type2Diabetic Patients And Non-diabetic Patients

Objective:To discuss the characteristics of coronary artery disease in type2diabetic patients, by analysing the coronary artery feature between type2diabetic patients and non-diabetic patients with the help of dual-source CT coronary angiography.Materials and Methods:From December2010to November2011, a total of261consecutive patients (63of type2diabetes,198of no-diabetes) who have coronary artery disease,complete clinical data and high-quality coronary images were examined with coronary dual-source CT angiography. All images were comprehensive assessed by the two radiologists who had experienced in cardiovascular diagnostic imaging at workstation. Distribution and types of plaques and luminal narrowing were evaluated. The Chi-square test or Independent sample t-test was used to compare the differences between type2diabetic patients and non-diabetic patients. A P-value of less than0.05was considered statistically significant.Results:The average coronary lesion number per patient was2.6±1.1,2.0±1.0coronary vessels and4.6±3.0,3.0±2.0segments in type2diabetic patients and non-diabetic patients, repectively(each P<0.05).Multi-vessel and diffused disease were more frequently detected in the type2diabetic patients than in the non-diabetic patients(P<0.05). Patients with type2diabetes had more plaques, especially mixed plaques and non-calcified plaques than non-diabetic patients(P<0.05). The mixed plaques were more (43.6%) and calcified plaques were less (28.1%) frequently detected in type2diabetic patients. There were more plaques that caused mild narrowing, moderate narrowing and severe narrowing in type2diabetic patients (each P<0.05). The obstructive stenoses were more frequently detected in the diabetic patients than in the non-diabetic patients (P>0.05). The most common vessel of disease in type2diabetic patients was the LAD artery, followed by the RCA artery and LCX artery, the least was LM artery. The most common vessel of disease in non-diabetic patients was the LAD artery, followed by RCA artery, LCX artery and LM artery. The vessel of disease in type2diabetic patients, such as RCA artery, LCX artery, LM artery (each P<0.05), was more common than in non-diabetic patients. No significant differences could be found LAD artery between type2diabetic patients and non-diabetic patients,(P>0.05). In type2diabetic patients, the obstructive stenosis of vessel was not significantly difference between males and females(P=0.231). However, sex difference in non-diabetic patients was significantly difference (30.5%males,16.5%females, P=0.020).Conclusions:1. Multi-vessel and diffused disease is more frequently observed in type2diabetic patients.2. Patients with type2diabetes have more plaques which were mainly mixed plaques.3. Obstructive stenoses are more frequently detected in type2diabetic patients. There is no relationship between the obstructive stenosis and sex.