Effectiveness Of Antithymocyte Globulin Therapy With Or Without Cyclosporine And Human Hematopoietic Growth Factors In Children With Acquired Aplastic Anemi

Hematopoietic stem cell transplantation cures aplastic anemia and has beenmade the treatment of choice for young patients who have suitable stem cell donors,whereas immunosuppressive therapy is the first-line treatment for most patientswithout suitable donors [1].Antithymocyte globulin has been the standard immunosuppressive regimen foraplastic anemia for many years and has demonstrated a40-50%response rate whenused alone [1,2] and a60-70%response rate when combined with cyclosporine [3]with35%relapse rate and the development of clonal diseases a significant problem toresponders [4,5].This paper reports a case of a child with acquired aplastic anemia managed with pigAntithymocyte globulin (p-ATG) and a review of literature on the effectiveness inclinical use of Antithymocyte globulin either as a monotherapy or in combinationtherapy with cyclosporine including or excluding human hematopoietic growthfactors for the management of acquired aplastic anemia in children...