Changes Of Potassium Channel In The Peripheral Blood Lymphocytes Of Patients With Hypertension In Xinjiang Kazakh

Objective: None research about the correlation between the essential hypertensionand potassiumion is reported at present, on this subject,we study the expression changes ofKv1.3and IKCa1potassium channel in peripheral blood lymphocytes from Kazakhhypertensive patients, to provide the experimental basis for exploring the pathogenesis ofhypertension. Methods：Randomly selected20without antihypertensive drug therapy forhypertension in Xinjiang Kazakh group of hypertensive patients age(50.2±3.8)years inDepartment of Cardiology and hypertension clinic service at the First Affiliated Hospitalof Xinjiang Medical University in September2010to September2011, then choose thesame period20cases of healthy people as control group age(49.1±3.6)years, two groupsof men and women10.Collect the peripheral blood lymphocyte of the hypertension andcontrol subjects. Use the technology of real time quantitative PCR(Real-time PCR) andwestern blotting to detect lymphocyte Kv1.3and IKCa1channels gene and proteinexpression level. Results: Both in the Kv1.3and in the IKCa1channels, theexpression levels of mRNA and protein in hypertension subjects is higher than in controlgroup(P<0.01). Conclusion: The study showed that increased expression of Kv1.3andIKCa1channels in lymphocytes of patients with hypertension, initially prompted thepotassium channel Kv1.3and IKCa1may be associated with hypertension and may beinvolved in the activation of lymphocytes in patients with hypertension.