The Influence Of Aerobic Training Combined With Resistance Training On The Insulin Resistance And Blood Lactate Of Type2Diabetes

Objective:The present study is to observe the relationship between blood lactate and type2diabetes as well as the changes after the intervention of aerobic training combined with resistance training. Investigate the effect of the exercise for type2diabetes and the clinical significance of blood lactate level in type2diabetes.Methods:80type2diabetes outpatients with no complications and another20normal healthy people were recruited to observe the relationship between blood lactate and type2diabetes. Then38type2diabetes patients were divided into two groups randomly:the conventional therapy group (N=22) and the advanced exercise therapy group (N=16). The conventional treatment group was treated by regular medication combining with the guidance of diet and exercise; the advanced exercise, on the contratry, utilizes a one-to-one guiding exercise therapy(36times, for eight weeks) besides the traditional treatment. Each exercise session includes:aerobic training (AT),30-45minutes/time; resistance training (RT),50-55%1RM (one Repition Maximum,),3times/week. All the groups were supplied by75g glucose to measure fasting blood glucose (FBG),2-hour postprandial blood glucose (PBG), fasting insulin(FIN), postprandial plasma Insulin,(PIN), glyccated hemoglobin (HbAlc) and blood lactate (Lac).Futhermore the conventional treatment group and the advanced exercise therapy group were asked to take the retests after8weeksResults:(1) In the diabetic group, the level of Lac was significantly increased compared with the normal control group (P<0.01). The level of Lac and FBG (r=.268, P<0.05), PBG (r=0.323, P<0.01), FIN (r=0.411, P<0.05), PIN (r=0.251, P<0.01), HbAlc (r=0.307, P <0.01), IRI(insulin the Resistance the Index)(r=0.292, P<0.01) were positively correlated, correspondingly.(2) After the8week-treatment, the FBG, PBG, PIN, HbAlc, Lac and IRI levels of both group were significantly decreased (P<0.01). There was no significant change (P>0.05) of FIN level in the conventional therapy group. However, the FIN level of the advanced exercise group was significantly decreased (P <0.01).(3) After treatment, comparing with the conventional therapy group, the levels of PBG, PIN, HbAlc, Lac and IRI in the advanced exercise group were significantly decreased (P<0.01or P<0.05)Conclusion:(1) The intervened of the advanced exercise treatment (aerobic training combined with resistance training)for type2diabetes was effective,and its mechanism may be related to improve insulin resistance.(2) The blood lactate level of type2diabetes was rised, comparing with the healthy people. Furthemore, after intervened (include conventional therapy and the advanced exercise therapy), the levels of blood glucose and blood lactate were all decreased, suggesting that the blood lactate may be used as a clinical indicator for the type2diabetes.