| Objective:To investigate the correlation between serum Myostatin and muscle strength, body composition, bone mineral density(BMD) in postmenopausal women of Changsha region.Methods:The serum Myostatin, bone alkaline phosphatase (BAP), C-terminal telopeptides of Type I collagen (CTX) of175postmenopausal women aged from51to75years were measured by enzyme-linked immunosorbent assay (ELISA). BMD of total body, lumbar spine, the left femur, fat mass and lean tissue weight were evaluated by dual energy X-ray absorptiometry (DEXA). Determination of the subjects of the right hand grip strength and stand up test time as indicators of muscle strength.Results:No statistically significant differences were found in the levels of Myostatin, muscle strength between women in the two groups: osteoporotic or not. There was no statistically significant difference in the correlation between Myostatin and muscle strength, body composition, BMD, BAP and CTX. Both fat mass and lean mass were positively correlated with BMD at all sites. CTX was negatively correlated with BMD of at all sites(P<0.05). BAP was negatively correlated with BMD of lumbar spine and total body (P<0.05). After controlling for age, age at menopause and height, Fat mass was the most significant determinant of BMD at the lumbar spine with a higher R2change and a partial R2compared with other variables, while lean mass had more impact on the femoral neck and the total hip values.Conclusion:In postmenopausal women of Changsha region, there was no statistically significant difference in the correlation between Myostatin and muscle strength, body composition, BMD, BAP and CTX. Myostatin was not the important determinant factors of BMD, BAP and CTX, both fat mass and lean mass were positively correlated with BMD at all sites. Fat mass was the most significant determinant of BMD at the lumbar spine, while lean mass had more impact on the femoral neck and the total hip values. |
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