| Objective:To investigate the relationship of body composition (fat mass and lean mass components) with age,menopausal age (MA), years since menopause (YSM) and its effects on bone mineral density (BMD) at posteroanterior spine and hip in postmenopausal women.Methods:Fat mass,lean mass and BMD at posteroanterior spine and hip were measured by dual-energy X-ray absorptiometry (DXA) in 919 healthy postmenopausal women.Results:Lower body fat mass (LF), whole fat mass (WF)and whole lean mass (WL) were all correlated with age,MA and YSM significantly (P<0.05-0.01),while only YSM entered the multiple stepwise regression equation of LF,WF and WL;complex or cubic regression model was found to be the best to describe the changes of body composition with respect to YSM; body composition had a downward trend with YSM; LF and WL reduced significantly in the women with YSM over 10 years, which were 8.6%and 3.1%,respectively, compared to the women with YSM within 5 years.All regional body composition was positively correlated with all regional BMD (P<0.05-0.01)(except the trunk lean mass with the BMD of L1, femoral neck and interal region of trochanter, P>0.05);after controlling body weight, only WF was related to BMD at posteroanterior spine (P<0.05),while WL was related to BMD at hip (P<0.05).Multiple stepwise regression analysis revealed that body composition was an important variable affecting BMD at posteroanterior spine and hip;WF was the main determinant of BMD at posteroanterior spine and WL was the main determinant of BMD at hip. WF and WL were lower in women with lower BMD. And the difference of WF and WL among different BMD groups was significant.Conclusion:(1)In postmenopausal women, body composition is related with age, MA and YSM; YSM is the most significant influencing factor of body composition. (2) In postmenopausal women, WF and WL are important influencing factors of BMD at the lumbar spine and hip, respectively.
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