Prevalence Of Hepatic Steatosis And Expression Of Fatty Acid Binding Protein In Liver Tissues Of HBV-associated Hepatocellular Carcinoma Patients

Background and purpose:Hepatitis B virus (HBV) chronic infection is one of the main causes of hepatocellular carcinoma(HCC) worldwide. Recent studies have revealed abnormal lipid metabolism and related lipid signal transduction may be one of the pathogenesis of cancer. But to HBV-associated HCC, the situation of hepatic steatosis and the expression of fatty acid binding protein(FABP) are seldom reported.Methods:335HBV-associated HCC liver biopsy tissues and1181chronic hepatitis B liver biopsy tissues stained by H and E were collected to investigate the prevalence of hepatic steatosis. The expression of FABP was identified by immunohischemistry in96HBV-associated HCC liver biopsy tissues and68chronic hepatitis B liver biopsy tissues.Results:The prevalence of hepatic steatosis in the tissues of HCC patients is significant higher than chronic hepatitis B patients (60%vs39.04%, p<0.01).According to0-5liver histological steatosis grade, most of the HCC are in1-2grade (53.4%). The expression of FABP in the tissues of HCC patients is significant higher than chronic hepatitis B patients (75%vs20.6%, p<0.01), according to0-4liver histological grade, most of most of the hepatocellular carcinoma are in1-3grade (69.8%). Conclusion:Both hepatic steatosis and related lipid signal transduction protein-FABP are involved in the pathogenesis of HBV-associated HCC and worthy of further research.