The BAG2Upregulates PINk1through Decreases Their Ubiquition

Parkinson disease (PD) is a common movement disorder and mutations in PINK1which encodes a mitochondria targeted kinase are the major cause of autosomal recessive, early onset PD. The study reported that BAG2interacted with PINK1and PINK1-R492X in vivo and in vitro by Co-IP and Pull-down. Then it found BAG2increased the levels of PINK1and PINK1-R492X, remarkably mutant PINK1-R492X deeply influenced. At last Co-IP experiment proved that wild-type PINK1and mutant PINK1-R492X can be deubiquitinated by BAG2via the ubiquitin-proteasome system. Therefore, it proposes a hypothesis that BAG2、PINK1/PINK1-R492X and ubiquitin ligase form a complex, which can regulate the degradation of PINK1/PINK1-R492X, and the complex affects the occurrence of Parkinson’s disease. The study proves that the BAG family plays a great role in the pathogenesis of Parkinson’s disease.