Clinical Study On Effect In Treating Stage Ⅳ Diabetic Nephropathy With The Method Of Yi Qi Tong Luo Xiao Zheng

Objective:To observe the effect in treating Stage IV Diabetic Nephropathy with themethod of Yi Qi Tong Luo Xiao Zheng(YQTLXZ), and discuss the mechanism of action.Methods: First the60patients with Stage IV Diabetic Nephropathy were asked for atwo-week elution period,and then were randomly divided into two groups with the ratio of1:1according to the order of the clinic,the experiment group and the control group.Patientsin the experiment group(30cases) were administered with traditional Chinese medicineYiQi Tong Luo（YQTL200ml per time, twice times a day),while those in the controlgroup(30cases)treated with Losartan capsule（80mg,qd）.Total therapeutic course was12weeks,and then the changs of urinory proteion per24hrs，kidney function, blood lipid,fibrinogen and the d-dimer, c-reactive protein,the efficacy of Chinese medicine for individualsymptoms of DN, total efficacy of Chinese medicine symptoms and the total clinical effects of thepatients were observed before and after treatment in two groups.Results: After the treatment, the CHO, LDL of the patients were significantly reduced in the experimentgroup(P<0.01),while TG was lower(P<0.05),HDL was highter（P<0.05）.The CHO, LDL were reducedin the control group(P<0.05),but the reduction of TG,HDL were of no statistical significance(P>0.05).While compared with the control group after the treatment, the reduction of CHO in the experimentgroup was significantly reduced (P<0.01), and the reduction of LDL was of statistical significance(P<0.05).The c-reactive protein of the patients in the experiment group was lower after thetreatment(P<0.05),while in the control group, its reduction was of no statisticalsignificance(P>0.05).The urinary protein per24hrs of the patients in the experiment group wassignificantly reduced (P<0.01), and its reduction was of statistical significance in the controlgroup(P<0.05).While compared with the control group after the treatment, the difference between thetwo groups was significant(P<0.01). The fibrinogen and the d-dimer of the patients in the experimentgroup were lower after the treatment(P<0.05),but the reduction of fibrinogen was of statisticalsignificance (P<0.05)while the reduction of the d-dimer was of no statistical significance (P>0.05). And compared with the control group after the treatment, the differences were both of statisticalsignificance(P>0.05).The efficacy of Chinese medicine for individual symptoms of DN, total efficacy ofChinese medicine symptoms and the total clinical effects of the patients in the experiment group weresignificantly improved（P<0.05）.Conclusion: YQTL has a good therapeutic effect for the treatment of DN，which has the function ofimproving the clinical symptoms,reducing24-hour urinary protein,regulating blood lipid，antifreezing,controlling inflammatory indices.It is proved that multiple-targeted intervention isavailable and effective in the prevention and treatment of DN.