Analysis Of Hazards Factors Of Type 2 Diabetes With Nephropathy And Study On Plasma Thrombomodulin And D-Dimer Levels In The Patients With Diabetic Nephropathy

Diabetic nephropathy is the main cause of iroitidity and rrotality in patients with diabetes rrellitus. It is also the most prevalent cause of end-stage renal disease (TESRD) throughout the industrialized vwdd. Therefore it is becoming an important task fir diabetic study todiagnoee and therapy diabetes at early stage. In this topic, we studied the hazard factois of type 2 diabetes with nephropalhy and explored the effect ofthese iadors on the padrcgen^ of diabetic nephropathy. We also measured plasma thrombomodulin and D-dimer of type 2 diabetes patients with cMerent stage of diabetic nephropathy.PARTI ANALYSISOFHAZARDFACTORSOFTYPE2DIABETES WITH NEPHROPATHYWeanalyzed the clinical data of 309 diabetic patients with nephropathy and 383 diabetic patients without nephropathy. We concluded that duration of diabetes, BMI, TC, LDL, IHD, hypertension, DR were significantly related to the occurrence of diabetic nephrcp%.SnKidng and DNP also increased the relative risk of the occurrence of diabetic nephroparhy,l3ut they had r?statistical significance,PART2 STnLJDYONPIASMATHROMBOMODlJIJNAM)I>DIMERI^VELSIN THE PATIENTS WITH DIABETIC NEPHROPATHY Objective: To measure the plasma levels of thrarnbonxckilirXTM) and Ekfcner(D-D) inpatients with diabetic nephropathy and to study the significance of TM and D-D in the pathogenesis of diabetic nephropathy.Method^: The plasma level ofTM and D-D were measured by ELISA in 58 cases withtype2 diabetes mellitus and 21 control subjects. The relationship between TM or D-D and glucose, lipid profile, blood pressure, renal function and diabetic complications was also investigatedResults: The plasma levdofTM and D-D were higherin the diabetic patients than those in the control subjects. It was also significant higher in the diabetic patients with nephropathy than those without nephropathy. The plasma TM level was higher in C!RF group than those in MAC and MIC groups, and it was also higher in MAC group than those in MC group (pO.05).In the diabetic patients, the plasma levels ofTM were positively correlated with BUN, CRE, UMA, DR,hypertension, and D-D. The plasma levels ofD-D were positively conelated with age, FPG, BUN, CRE,UMA,DR.Conclusions: The plasma levels ofTM ate effected by renal function. Plasma TM levels in diabetic patients might be predictors for very early nephropalhy. Older, hyperglycernia, and impaired renal function could induce hypeiroagulation in diabetic patients.