The Preliminary Study Of SATB1and E-Cad Expression In The Gallbladder Carcinoma And Its’ Significance

Objective: To study the expression of SATB1，E-Cad in gallbladder carcinoma andexplore they interrelation and they relationship with tumor development, biologicalbehavior.Search biology symbol for the early diagnostic，analysis prognosis andeffective therapeutic of gallbladder carcinoma.Method: collect the First Affiliated Hospital of Anhui Medical University in2005-2010years between surgery and pathologically confirmed in39cases ofgallbladder carcinoma specimens. The other23specimens taking the homeochronousgallbladder tissues because of calculus or adenoma. all patients were not receivingchemotherapy or radiotherapy before surgery，and a complete follow-up data. Usingimmunohistochemical staining (SP) to detected the expression of SATB1protein andE-Cad protein in two gallbladder group. use the statistical methods for analyse thedata.Result:1. The positive rates of SATB1was66.7%in gallbladder carcinoma was significantlyhigher than the expression in control group, which were20.0%and25.0%(P<0.05).The positive rates of E-cad was28.2%in gallbladder carcinoma was significantlylower than the expression in control group, which were93.3%and100%(P<0.001).2. the expression of SATB1in gallbladder carcinoma was connected with tumor grade,clinical stage，lymph node and far diversion(P＜0.05). the expression of E-cad ingallbladder carcinoma was connected with tumor grade and clinical stage(P＜0.05).3. There was a significant negative correlation was discovered between the expression of SATB1，E-Cad in gallbladder carcinoma (P<0.05).4. tumor grade, clinical stage，the expression of SATB1，E-Cad were independentfactor in the prognosis of gallbladder carcinoma patients(P<0.05).conclusion1. The positive rates of SATB1was66.7%in gallbladder carcinoma was significantlyhigher than the expression in control group, The positive rates of E-cad was28.2%ingallbladder carcinoma was significantly lower than the expression in control group.2. There was a significant negative correlation was discovered between theexpression of SATB1，E-Cad in gallbladder carcinoma (P<0.05).3. the expression of SATB1in gallbladder carcinoma was connected with tumor grade,clinical stage，lymph node and far diversion(P＜0.05). the expression of E-cad ingallbladder carcinoma was connected with tumor grade and clinical stage(P＜0.05).4. The expression of SATB1，E-Cad were independent factor in the prognosis ofgallbladder carcinoma patients,and There was a negative correlation between SATB1and E-Cad expression. Conjoined detect the expression of SATB1，E-Cad might be anuseful reference index for the early diagnostic，analysis prognosis and effectivetherapeutic of gallbladder carcinoma.