The Research Of Of Error Monitoring And Attention Networks In The Patients With Obsessive-compulsive Disorder

Objective To investigate the function of error monitoring and attention network inpatients with obsessive-compulsive disorder (OCD).Methods53OCD patients and36healthy subjects were tested with the errormonitoring task and attention network test.Results In the error monitoring task, There are significant differences between thepatients with OCD and heath controls on Full Correct(FC)、the numbers of uncertain、the numbers of dropout、the reaction time(RT) of choice and the RT of trail in the errormonitoring task(t=2.080，P=0.040；t=-2.015，P=0.047；t=-3.948，P=0.000；t=-3.489，P=0.001；t=-3.388，P=0.001). In the attention network task, the comparison between thepatients with OCD and healthy subjects on the RT of the alerting network wassignificant differences (P=0.027) in the attention network test. There was a significantlycorrelation between attention network and error monitoring; significant differences wereobserved at study endpoint in the RT of choice、the RT of assessment and the RT of trailof patients who used SSRIs compared with those who did not(t=2.275，P=0.029；t=2.367，P=0.022；t=3.002，P=0.004). There was no significant correlation betweencourse of disease and error monitoring, while there was significant correlation betweenthe scores of PI-WSUR、the numbers of uncertain、the numbers of dropout and errormonitoring.Conclusion The impairment of the error monitoring as well as attention network inpatients with OCD what is not related with the SSRIs may be involved in thedisfunction of anterior cingulate cortex（ACC）.