The Preparation Technology And Quality Standard Of Xiong-Bi Patch

The acupoint administration commonly used method of clinical medicine, it has to avoid first pass effect, does not damage the stomach and reduce drug side effects, saving the amount of drugs, targeted, and other advantages, its role is more durable and slow, painless non-invasive, suitable for long-term administrationis a suitable mode of administration of the Chinese medicine treatment.The prescription of Xiong-bi patch derived from clinical experience side,it consists of Astragalus, Salvia, Corydalis, and Chuanxiong clinically used for the adjuvant treatment of angina, with a significant therapeutic effect. Without changing the composition of the original prescription foundation, developed a new dual-layer acupuncture points (Xinyu, neiguan, Sanyinjiao) the administration of topical patches.Prescription in the extraction and purification of various herbs can effectively increase the drug loading of Chest paste. Similar polarity and solubility of the active ingredients contained due to Salvia, Corydalis, and Chuanxiong select synchronization extract; In order to improve the purity of the active ingredients of Astragalus in saponin class, separate extraction. Tanshinone Ⅱa and total alkaloid content of the indicators, using a60℃reflow and the comparison of the ultrasonic extraction method, preferably Salvia, Corydalis, and Chuanxiong best extraction method, and further by the orthogonal experiment to determine the optimum extraction process; Astragalus refluxed best alcohol extraction process of extraction, determined by orthogonal experiments, in order to further remove impurities, preferably out of the D101resin, refined extract of astragalus.Molding process using polyethylene glycol1000and polyethylene glycol2000as a reinforcing material, the use of the drug extract-based medicine, the use of yellow Achillea tree powder for the outer layer of adhesive was prepared as a double paste ointment and orthogonal optimization of internallayer and the outer layer of material consumption.In order to gain a better understanding of Xiong-bi patch sticking performance, investigated the adhesion conferred and load difference; the use of transdermal and release experiments, to study its bioavailability. On this basis, the TLC of the (Salvia, Corydalis, Astragalus) and determination of (tanshinone Ila and Astragalus A glycoside) to establish the quality standards of Chest affixed.Compared with the same type of patch,we developed the new type of double acupoint paste has large amount of drug loading, easy to store, easy to change, high stability, use does not have a drug flow phenomenon, to achieve the purpose of transdermal drug delivery, the designated administration better. Therefore, the feasibility of Xiong-bi patch production process. Double Point administration has a strong innovation, has been the national utility model patents. The establishment of quality standards can effectively evaluate the quality and control. The study laid the foundation for the development of topical formulations of new angina.