Effects Of Alcohol Intake On Coronary Collateral Circulation And Serum Level Of VEGF In Myocardial Infarction

Objective:Coronary artery disease(CAD) is one of the important diseases that endanger human health, and researches of the relationship between alcohol consumption as a regulated lifestyle and coronary artery disease have been carried out nearly30years. Coronary collateral circulation in acute myocardial ischemia can protect myocardium, reduce myocardial necrosis area, reduce sudden death rate, and save time for reperfusion therapy. Formation of collateral circulation requires vascular endothelial cell proliferation. Vascular endothelial growth factor (VEGF) and is an important factor to promote proliferation of endothelial cells, which can promote angiogenesis quickly and effectively, and the establishment of collateral circulation in myocardial infarction in patients. In this study we investigat the differences of levels of collateral circulation and VEGF levels in CAD patients with different amounts of alcohol consumption, to explore the relationship between alcohol consumption and level of collateral circulation in patients with CAD.Methods:Male patients with CAD were select as research objects with complete occlusion in at least one major blood vessels (left anterior descending artery, left circumflex artery and right coronary artery) confirmed by coronary angiography in Provincial Hospital Affiliated to Shandong University from November2010to August2011. Coronary artery disease was analyzed with the QCA systems and coronary collateral circulation was classified with Rentrop scoring system according to the results of coronary angiography. Patients’daily alcohol consumption was learned with questionnaire method including weekly drinking frequency, each alcohol consumption and alcohol types as well as other coronary heart disease factors such as blood pressure, HDL, TG and LDL, fibrinogen, smoking and diabetes. Patients with infection, malignant tumors, cerebrovascular disease, peripheral vascular disease, liver and kidney dysfunction and immune system disorders were excluded. According to alcohol intake patients were divided into three groups:36patients in non-drinking group,33patients in light-drinking group (average dai ly alcohol intake≤40g)and34patients in heavy-drinking group(daily alcohol intake>60g). Patients arterial blood was taken and centrifuged. Serum levels of VEGF were detected with ELISA.Results:Coronary collateral circulation in light-drinking group was better than that of non-drinking group and heavy-drinking group; serum level of VEGF in light-drinking group was significantly higher than that in non-drinking group(148.32±60.80pg/ml vs113.53±61.82pg/ml), while there was no significant difference between the light-drinking group and the heavy-drinking group.Conclusion:Light-moderate alcohol intake may be better to the establishment of collateral circulation in patients with coronary artery disease which may be associated with increased VEGF expression.