Study On Toxicology And Pharmacokinetics Of New Drug Abuse2C-B

2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a kind of new drug abuse which can produce euphoria, with the increase of the dosage for human body to produce different degrees of mentation. In recent years2C-B is found frequently in some Asian countries including China, to cause serious harm for the human society. When we struggle with criminals, at the same time, should proceed further research with each drug abuse, to fully understand the metabolism process and poisoning addiction mechanism, to provide theoretical basis for addicts withdrawal and clinical treatment. This article for the first time proceed2C-B experimental analysis of toxicology and pharmacokinetics, which can provide data material and lay the foundation for the further research of2C-B and2C-series. The main research contents and the results are as follows:Though acute toxicity experimental of the2C-B in mouse, they are determined that LD100about270mg/kg、LD0about200mg/kg、LD50about234.11mg/kg, which can provide basis for the dose choice of long term toxicity test.Though the effects of2C-B on the the organ index、blood routine、blood-biochemics、histopathology of male and female rats after five months and one month withdrawal, to process long term toxicity test of the2C-B in rat. Results show that it effects tiny for the low dose group, high doses of group and medium dose group of influence obviously, after rats long term oral administration2C-B. All of the changes and the lesions of brain、heart、liver、lung、kidney are compacted, and they can not resume in the one month. Indicating that these organs may be target organs of2C-B toxic effect, and no significant differences between male and female rats.The determine method for2C-B in blood samples though the GC is established successfully in this dissertation. Though the system assessment we know the specificity、 linear relationship、reclaim rate、precision and stability of this method are good, accord with the determination requirements of biological samples. According to the method to determine blood drug level of2C-B at different time points and different administration dosages, and handling these data by3P97. Though the pharmacokinetics parameters of2C-B, we know the half life periods is irrelevant with dosage, Cmax and AUC increase with the dose increase exponentially, show2C-B10-40mg/kg is one compartment model. The Ka、Ke、 T1/2Ka、T1/2Ke、Tmax are no significant differences between male and female rats, Cmax and AUC of the female rat is higher, CL/f、V/f is lower than them of the male rat.Though above experimental results, we hope it can provide the reference for preventing injury and clinical treatment.