"fuji" Mushroom Powder, Anti-tumor, Reduce The Toxic Side Effects Of Chemotherapy Drugs And Toxicology Studies

Object: To study fujinokinoko's antitumor,reduce chemotherapy side effects and toxicological effects.METHODS: MTT and serum pharmacology method was used to observe fujinokinoko's effect of Hela cells, H22 cells, 803 cells, MCF7 cells, Co261u cells, Hep-2 cells, A549 cells growth inhibition. NK cell activity method was used to observe fujinokinoko's capital guarding role of tumor-bearing mice immune system whom received cyclophosphamide chemotherapy. Using single-dose and 30 days feeding experimental to study fujinokinoko's acute and chronic toxicological characteristics.Results: fujinokinoko can markedly inhibit Hela cells, H22 cells, MCF7 cells, Co26lu cells, Hep-2 cells and A549 cells growth, and it can protect the chemotherapy drugs cyclophosphamide-induced immune system injury, fujinokinoko's LD₅₀ is 8.297g/kg and after a longer period of time (30 days) orally administration the rats showed no toxicity of pathological changes.Conclusion: fujinokinoko can inhibit tumor growth, reduce chemotherapy side-effects of drug function, and it will be safe for administration.