| Object:The study was to investigate antimicrobial resistance trends amongaerobic and facultative Gram-negative bacilli (GNB) isolated fromintra-abdominal infections at a teaching hospital between2008to2010.Methods:to collecte gram-negative bacilli from patients with intra-abdominalinfections from2008to2010. Antimicrobial susceptibility testing wasperformed using broth microdilution according to the NCCLS guidelinesfor MIC testing, and Extended-spectrum beta-lactamases (ESBLs) weredetected phenotypically in E. coli and Klebsiella spp.Results:A total of290aerobic and facultative GNB were isolated fromintra-abdominal infections. Enterobacteriaceae composed82.7%of thetotal isolates. E. coli was the most common isolate (55.3%), and therato of Acinetobacter baumannii Complex incereasing apprently. ESBLswere detected phenotypically in74.38of E. coli,55.56%of Klebsiella spp.,Among the agents tested, the carbapenems were the most consistentlyactive against the Enterobacteriaceae and Pseudomonas aerltgillosa, thenext one is piperacillin／tazobaetam. Among the non-fermentingpathogens, the susceptibility rates of Pseudomonas aerltgillosa to the twoquinolones, cefepime, amikacin and Ceftazidime were80%-90%,80–90%, 90%,<80%, respectively．The most isolates of Acinetobacter baumanniiComplex were resistant to12agents tested, including carbapenems.Multidrugs resistan strains account for32%.Conclusion:The carbapenems (ertapenem and imipenem), piperacillin／tazobaetam and amikacin are highly active in vitro againstEnterobacteriaceae isolated from intra-abdominal sites, includingorganisms that produce ESBLs. Antimicrobial resistance in GNB isolatedfrom patients with intra-abdominal infections continues to increase duringpast three years. The guidelines for IAI should revirsed becauseantimicrobial resistance among GNB isolated from intra-abdominalinfections is becoming a problem in the region. |
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