The Risk Factors And Bacterial Susceptibility Analysis Of Intra-abdominal Infections In Severe Acute Pancreatitis

Objective: The aim of the study was to find out the risk factors of the severe acute pancreatitis(SAP) with intra-abdominal infections(IAI) according to the retrospective analysis of the clinical data in patients with SAP in the past5years, and to analyze the bacterial spectrum, drug sensitivity in patients with IAI for clinical diagnosis and treatment.Methods: The clinical data of the SAP patients with IAI and with non-IAI were collected, and the relationship between the factors which have significant difference in the two groups and the SAP with IAI was explored according to the Logistic regression analysis. The ascite specimens and the necrotic tissues were harvested for bacterial culture and drug sensitivity analysis.Results: The Multiple organ dysfunction syndrome(MODS), seroperitoneum, Ca and intestinal dysfunction(ID) were the risk factors of SAP with IAI. The main pathogenic bacteria are gram-negative bacteria.The top two gram-negative bacteria were e. coli, pseudomonas aeruginosa; and the top two gram-positive bacterium were enterococcus, staphylococcus aureus.They werre generally not sensitive to common antibiotics.Conclusions: The therapy of early SAP with IAI should be basd on the risk factors, bacterial spectrum, and drug sensitivity, in order to increase the clinical therapeutic effect.