Critical Value Comparison Of NT-pro BNP At In Different Age In Diagnosis Of Acute Heart Failure

Objective: To calculate the cut-point of NT-pro BNP for detecting theacute heart failure in different age for patients with or without acute heartfailure, to provide the accurate criteria for diagnosing acute heart failure.Methods: SPSS19.0software was to analyze the material. Comparisons ofclinical characteristics between patients who had acute CHF and those whodid not were performed with chi-square tests for categorical data,Mann-Whitney for continuous variables. Receiver operating characteristics(ROC) analyze was used to establish the optimal cut-point for ruling-in andruling-out the diagnosis of acute CHF. Results: The cut-point ofNT-proBNP was1100pg/ml for patients aged≤50years, the diagnosis ofacute heart failure with the sensitivity of96%，specificity of88%，positive predictive value of81%，negative predictive value of98%andaccuracy of90%;1800pg/ml for patients aged50-70years, the diagnosisof acute heart failure with the sensitivity of90%，specificity of76%，positive predictive value of81%，negative predictive value of89%andaccuracy of82%；3000pg/ml for patients aged≥70years, the diagnosis of acute heart failure with the sensitivity of84%，specificity of73%，positive predictive value of70%，negative predictive value of87%andaccuracy of78%. They over all yielded88%sensitivity and77%specificityfor acute CHF. Conclusions: Selecting related cut-point of NT-proBNPfor different aged patients may elevate the practicablity and accuracy in theclinical diagnosis of acute heart failure.