Expression Of Stem Cell Related Genes In Endometrial Polyps

Objective To investigate the expression of ipo13、c-kit、CD146、bcl-2and bax in endometrial polyps and normal endometrial tissues andits clinicopathologic significance.Methods Collected40specimens of endometrial polyps tissues（case group） and40normal endometrial tissues （control group）in ourhospital from March to September in2010，each inproliferative andsecretory phase of the organization of the20cases. Expression of ipo13、c-kit、CD146、bcl-2、bax mRNA and（or） protein was detected byReal-time Quantitative Polymerase Chain Reaction (RT-PCR) andimmunohistochemical staining in all specimens.Results Whether in the proliferative phase or secretory phase of themenstrual cycle, the expression of ipo13、c-kit、 CD146and bax mRNAand protein in EP was significantly lower than normal endometrial tissues(P<0.05),the expression of bcl-2mRNA and protein expression was higherin EP compared with normal endometrial tissues in the same period（p<0.05）.Conclusion The expression of ipo13、c-kit、CD146、and baxmRNA and protein in endometrial polyps is significantly lower than that innormal endometrial tissues. While, bcl-2expression up-regulated in polyps.Our results suggested that endometrial stem/progenitor cells dysfunctionand endometrial cells apoptosis in decreasing related to endometrial polyps,endometrial stem/progenitor cells dysfunction causing endometrium apoptosis reduction may be the main reason for the occurrence anddevelopment of endometrial polyps.