Impacts Of5Diferent Anti-hypertensive Agents On Blood Pressure Variability

BackgroundBlood pressure variability (BPV) means the fluctuation of blood pressure level in a period of time. In recent years researches around the world have shown that abnormal BPV can cause damage to the heart,brain,kidney and other target organs. BPV can be used as a separate predictor of cardiovascular events. Effective reducing of BPV in these patients with hypertension is very important to improve the prognosis.ObjectivesTo observe the impacts of5diferent anti-hypertensive agents(indapamide, enalapril, valsartan, amlodipine, metoprolol) on BPV in patients with essential hypertension(EH).Methods and contentThis is a retrospective study. Reviewed five Phase Ⅱ or Ⅲ Clinical Trials which were done at Key Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health,Cardiovascular Institute and Fuwai Hospital in2000-2009,according to the inclusion and exclusion criteria,collected the clinical information of118patients with EH who were treated with indapamide, enalapril, valsartan, amlodipine, metoprolol,respectivel. The changes of24hour,daytime and nighttime average blood pressure and BPV which were provided by ambulatory blood pressure monitoring(ABPM) were compared prior to and after8weeks of treatment.ResultsAll of these five kinds of antihypertensive drugs can reduce blood pressure. Compared with other drugs,amlodipine lowers blood pressure the most.In the five kinds of drugs valsartan, indapamide, amlodipine reduce individual BPV at most time,and valsartan reduces individual BPV the most versus others, the second one is indapamide.Conclusion The five kinds of antihypertensive drugs can reduce blood pressure in patients with hypertension;and these drugs have different effection on BPV in hypertensive patients.