| Purpose：To investigate the relationship between urinary nerve growth factor (NGF) andoveractive bladder (OAB) in order to provide novel theoretical basis on clinicaldiagnosis Saba statistical analysis is made according to the severity classification, age,gender and concentration of NGF in the urine from the healthy group and patientswith OAB.Methods：40patients first diagnosed as OAB without any treatment in the Urologydepartment，Beijing Haitian Hospital from December2010to February2012and30adult with similar constituent ratio of age and gender were selected as normal controls.All urine samples were obtained from OAB patients and controls at an urge sensationto void, and the concentration of NGF is measured by ELISA, The total urinary NGFlevels were further normalized to the concentration of urinary cretonne (NGF/Crlevel). ANOVA or and T Test were used for statistical analysis via SPSS17.0, A valueof P <0.05was considered statistically significant.Results：(1) OAB patients urinary NGF/Cr is significantly higher than normal controlgroup＜0.05,the data has statistical significance.(2) The urinary NGF/Cr in different severity of OAB in comparison, P <0.05, thedata has statistical significance.(3) The urinary NGF level of OAB patients is higher in whose condition is moresevere.(4) OAB patients urinary NGF is not statistically correlated with age and gender.Conclusion：(1) The normal individual has the physiological urinary NGF production.(2) Most patients with OAB have high level of urinary NGF，suggests NGF mayplay an important role in the pathogenesis of OAB, and it may be used as a biomarkerof OAB. (3) OAB patients urinary NGF level and OABSS score have positive correlation,suggests that urinary NGF may be used as an objective index of severity.(4) Urinary NGF of OAB patients is not statistically correlated with age andgender.(5) Urinary NGF is a simple, noninvasive and objective biomarker of Obit has ahigh sensitivity and specificity in diagnosis of OAB. |
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