Efficacy Of Female Patients With Overactive Bladder Treated With Percutaneous Tibial Nerve Stimulation

Objective:To investigateanalyze the clinical efficacy of percutaneous tibial nerve stimulation (PTNS) for Chinese female patients with overactive bladder.Methods:212overactive bladder(OAB) Chinese female patients were randomly divided into three groups.The PTNS group:patients were received percutaneous tibial nerve stimulation therapy once a week for12weeks(n=70).The M receptor blockers group:patients were received M receptor blockers(Tolterodine Tartrate Tablets2mg2times per day) for12weeks(n=73).The combined treatment group rpatients were received PTNS combined with M receptor blockers therapy mentioned above for12weeks(n=69). The patients underwent a physiotherapeutic evaluation that included the overactive bladder symptom score(OABSS), mean daily voids episodes, mean daily urinary incontinence episodes,et al.inary incontinence episodes,et al. The PTNS group received the second12weeks’PTNS treatment, and part of the patients with an initial positive response to24weekly percutaneous tibial nerve stimulation treatments continued the PTNS therapy (once a week for24weeks and Once every2weeks for the next24weeks).ResultThe overactive bladder symptom score (OABSS) declined significantly before and after treatment in each group(The M receptor blockers group:8.7±1.8vs6.3±1.6;The PTNS group:8.8±1.7vs6.5±1.9;The combined treatment group:8.9±1.9vs5.8±1.6.P<0.05), and all the mean daily voids episodes, mean daily nocturia episodes,mean daily urinary incontinence episodes,daily urgency episodes and mean vloume per void declined significantly before and after treatment in each group(P<0.05). There were no significantly difference in OABSS between PTNS group and M receptor blockers group(P>0.05). The overactive bladder symptom score(OABSS), mean daily voids episodes, mean daily nocturia episodes,mean daily urinary incontinence episodes,daily urgency episodes and mean vloume per void declined significantly in the combined treatment compared with the other two groups(P<0.05).At the end of the second12weeks’ PTNS treatment in the PTNS group (4patients lost to follow-up in the first12weeks’PTNS treatment,4patients dropped out the the second12weeks’PTNS treatment and2patients lost to follow-up in the second12weeks’PTNS treatment.n=620),The OABSS fell from6.5±1.9to6.1±1.9(P<0.05). The22patients which were randomly assigned from the43patients with an initial positive response to24weekly percutaneous tibial nerve stimulation treatments continued the PTNS therapy (once a week for24weeks and Once every2weeks for the next24weeks),There was no significant change in OABSS during the next48weeks. Conclusions:Percutaneous tibial nerve stimulation(PTNS) provides good therapeutic effect for female primary overactive bladder and improves quality of life of patients. And the combination therapy provided significantly better outcomes than mono therapy.Most patients with an initial positive response to12weekly percutaneous tibial nerve stimulation treatments may safely sustained overactive bladder symptom improvement to72weeks with an average of1treatment every2weeks.