Study On The Correlation Of Mri Diffusion Tensor Imaging At Early Stage And Cognitive Function At Recovery Stage In Patients With Diffuse Axonal Injury

ObjectiveTo investigate the correlation of mri diffusion tensor imaging atearly stage and cognitive function at recovery stage in patients withdiffuse axonal injury (DAI).Methods1. Fifteen patients with DAI (2.80±1.85d post-injury) and fifteen healthyvolunteers were recruited in this study. The fractional anisotropy,apparent diffusion coefficient, axial diffusivity, and radial diffusivitywere quantified from different regions of interest includingcorticospinal tract, uncinate fasciculus, anterior corona radiata,superior longitudinal fasciculus, inferior longitudinal fasciculus, genuof the corpus callosum, body of the corpus callosum, splenium of thecorpus callosum, and cingulum bundle using Track and MRIcron software and were compared between DAI group and control group.2. Neuropsychological tests, including Mini-mental status examinationtest, Digit span backward, digit-symbol test, California verbal learingtest, Stroop color-word test, were applicated to value cognitivefunction between patients at recovery stage (17.26±4.31M post-injury)and healthy controls. Neuropsychological tests score were comparedbetween two groups. Then correlations between the parameters valueof DTI and neuropsychological tests score in DAI patients wereanalysed with Pearson linear correlation.Results1. There were no different statistics in age and gender between DAI andcontrol group. At early stage of DAI, there were different statistics inFA and AD value were observed in brain vulnerable areas of DAIpatients(P<0.05). Except the ADC value was increased significantlyin genu of the corpus callosum, body of the corpus callosum andsplenium of the corpus callosum(P<0.05), other ROI and RD valuedid not change significantly, compared to normal controls(P>0.05).2. There were no different statistics in education between DAI andcontrol group. At recovery stage, Scores of MMSE test were notchange significantly(DAI:28.46±1.24, Control:29.20±1.08, P=0.87),but scores of working memory tests and attention tests had differentstatistics(P<0.05) between DAI and control group. The FA value in corticospinal tract, uncinate fasciculus, anterior corona radiata,superior longitudinal fasciculus and inferior longitudinal fasciculuswere correlation with working memory total tests scores in DAIgroup(P<0.05); Meanwhile, the FA value in uncinate fasciculus,anterior corona radiata, superior longitudinal fasciculus, inferiorlongitudinal fasciculus and cingulum bundle were correlation withattention total tests scores in DAI group(P<0.05); The ADC value incorticospinal tract and Genu of the corpus callosum were correlationwith working memory total tests scores in DAI group(P<0.05); TheAD value in inferior longitudinal fasciculus was correlation withworking memory total tests scores; Other parameters of DTI in ROIwere no correlation with working memory and attention total scores.ConclusionsDetection of MRI diffusion tensor imaging at early stage in patientswith DAI could be helpful to predict different types of cognitivedysfunction at recovery injury.