| Objective:Stress is a biological body protection mechanism that can help individuals to adapt to environmental changes, to survive. Prenatal stress is a special maternal stress, which can be induced by everyday life events and external environment. Prenatal stress cause the materal hormone-releasing, these hormones through the placenta, role in the fetus, lead to the fetus suffered stress stimulation and damage fetal development. Anxiety was considered to be a normal stress response, and stress were closely related, but its pathogenesis was unclear. A large number of studies have found that many diseases have been related with the fetus early harmful experiences. Whether, there is a relation between anxiety and the fetus early harmful experiences? Thus, we using prenatal restraint stress to establish the prenatal stress model in the middle pregnancy (7-13d) and late pregnancy (14-20d). The prenatal restraint stress procedure is that pregnancy rats were given7days prenatal restraint stress,3times one day,45min per time. We test anxiety-like behavior when30days after the offspring born. Aimed to improve our knowledge in molecule mechanisms about offspring rats’anxiety-like behavior caused by prenatal restraint stress. And this may have beneficial to health care of newborn and pregnant women.Results:Prenatally stressed offspring rats who lived in the SPF environment reduced residence time in the central grid in the open field test, and there was no difference between male and female, between the middle and late; Prenatal reduced the residence time which the mid-stress group rats who lived in the general environment spented in the open arms in the elevated plus maze test. There were significant differences male and female in late stress group, the residence time the female spented in the open arm was significantly less than the male.Conclusion:Prenatal stress increased anxiety-like behavior of30-day-old offspring rats, and which effected by environmental factors. |
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