Clinical Study Of Correlationship Between Insulin Resistance And Endometrial Cancer

OBJECTIVE In this study, we try to investigate the possible role of insulinin the carcinogenic of endometrial cancer.METHOD Case were47women with newly diagnosed endometrial cancerfrom Affiliated Tumor Hospital of Guangxi Medical University.48controls werefemale patients admitted for non-endometrial conditions from the same hospital.All patients were measured for current weight，height. Fasting blood glucose（FBG）, fasting serum insulin (INS), estradiol (E2), luteinizing hormone (LH),follicle stimulating hormone (FSH) and prolactin(PRL)were measured.RESULT Fasting serum insulin levels and HOMA-IR of the cases wassignificantly higher (P <0.05), with the odds ratio（OR） of1.166(95%CI=1.093-1.244),1.663(95%CI=1.268-2.182) respectively. The association ofinsulin and endometrial cancer was changed but still remained after adjustment for E2and other confounders. The risk increased with increasing levels ofinsulin, and OR from bottom quintile to top quintile were1,1.160,9.310,27.929. The highest is27.929times of the lowest. The dose-responserelationship between insulin and endometrial cancer risk remained afteradjustment for other confounders. As for the correlations between insulin andsteroid hormones, insulin was positively related to E2,and inversely correlatedwith FSH.CONCLUSION The fasting serum insulin may be a risk factor independentassociated with endometrial cancer. There was a dose-response relationshipbetween insulin concentration and endometrial cancer risk. Insulin waspositively related to E2,and inversely correlated with FSH.