The Experiment Of Jianpijiedu Decoction On Psoriasis Model Mice

Objective: To observe the change of mice vaginal epithelium cell,the plasmaendothelin-1and serum soluble E-select element level after giving jianpijiedu decoctionto psoriasis model mice and to discuss the effect and mechanism of jianpijiedu decoctionfor curing psoriasis so as to provide experiment basis for clinical applications;Method:using the radiation immune method to determining the change of mice vaginal epitheliumcell,the content of plasma endothelin-1, and the content of Serum soluble E-selectelement onthe model mice;Result: Experiments1, the high, medium and low doses ofinvigorating spleen soup and above all A capsule detoxification can inhibit vaginalepithelial cell mitosis, compared with model group significantly, A statistically significant(P <0.05), in high dose of the spleen jiedu decoction and above A capsule; there were nosignificant differences The experiment2and3of the experiment, the high, medium andlow doses of the spleen detoxification above all can be A capsule soup and the lowering ofplasma endothelin1and serum soluble E-choose meat level, compared with model groupsignificantly, A statistically significant (P <0.05), in, high dose of the spleen jiedudecoction and above A capsule is no obvious difference;Conclusion: The effect ofjianpijiedu decoction in treating psoriasis might by means of blocking multiple Onset link,so the content variation of mice vaginal epithelium cell,Plasma endothelin-1and serumsoluble E-select element may serve as Pharmacodynamic index to provide experimentbasis for clinical applications ande relate with the dose.