The Clinic Annalysis Of Mycoplasma Pneumoniae Neumonia In Chilldren

Objective: To observe the change of Mycoplasma pneumoniae pneumonia (MPP) inchildren with clinical manifestations, blood routine test, liver function, myocardialenzymes, trace elements, etiology, humoral immunity, etc, and to investigate theirsignificance in the pathogenesis of Mycoplasma pneumoniae pneumonia. Methods: The289cases of inpatients of pediatric pneumonia in the Fifth Affiliated Hospital of XinjiangMedical University from September2010to September2011, according to the clinicalmanifestations, laboratory tests and imaging examination, were divided into Mycoplasmapneumoniae pneumonia group (136cases) and control group (153cases), the clinical datawas compared and analysed between the groups. Results: the average days offever,wheezing and Cough, were higher In the MPP group (P<0.05), and the cases numberof MPP group with pulmonary rales was less than that of control group (P<0.05). Thelevel of red blood cell count of the MPP group compared with the control group werehigher (P<0.05), The level of platelet counts was less than that of control group (P<0.05),but no significant difference was shown between the two groups in levels of white bloodcell count and hemoglobin (P>0.05). the average value of serum zinc and serum iron werelower than that in the control group (P<0.05), and the difference between the two groupswas not statistically significant in levels of serum calcium, phosphorus, magnesium andcopper content (P>0.05). The average levels of total bilirubin, indirect bilirubin, aspartateaminotransferase, creatine kinase enzyme and hydroxybutyric acid in the MPP group werehigher (P<0.05), direct bilirubin, alanine aminotransferase and alkaline phosphatase werelower than that in the control group (P<0.05), but there was no significant differencebetween two groups in lactate dehydrogenase (P>0.05). The positive rates of EB virusantibody lgM, anti-adenovirus antibody lgM, anti-Legionella pneumophila antibody LgM,anti-Legionella pneumophila antibodies LgM, anti-RS virus LgM, anti-parainfluenza virus LgM, anti-mumps virus and Coxsackie virus LgM in children with MPP were higher thanthat of control group (P<0.05). The levels of serum lgA and IgM in MPP group was higherand serum lgG lower than those of the control group (P<0.05), while the two groups wereno significant difference in terms of C3, C4, properdin factors B factor, pre-albumin,kappa lightchain and lambda light chain (P>0.05). Conclusion: Compared with thenon-MP infection pneumonia, the average days of fever, wheezing and Cough, werelonger In the MPP group. pulmonary signs are not obvious. the count of white blood cellgenerally is not high, the levels of red blood cell count, IgA and IgM are higher, but thelevels of platelet count,serum iron, serum zinc, and IgG are lower. Creatine kinaseisoenzyme has high sensitivity and specificity, elevated bilirubin is given priority to theindirect bilirubin. MPP is easy to mix a variety of infection of pathogen.The humoralimmunity may be related to the pathogenesis of MPP.