Two Kinds Of Surgery Efficacy In Patients With Localized Renal Cell Carcinoma:a Meta-analysis

Objective: The purpose of this study was to analyze Articles of nephron sparingsurgery (NSS) to radical nephrectomy (RN)for Localized Renal Cell Carcinoma (RCC), oftwo different surgical by means of the method of meta analysis, in order to provideevidence for clinical treatment of Localized Renal Cell Carcinoma. Methods: Aticlesincluding randomized controlled trials (RCTs) studies around the world about nephronsparing surgery (NSS) to radical nephrectomy (RN) for Localized Renal Cell Carcinoma(RCC), were searched by Pubmed, Ovid, CENTRAL(CochraneLibrary), EMBASE, CNKI,CBMdisc, VIP, WanFangData; studies were chosen at last for Meta-analysis.The data wereanalysed by REVMAN5.0software. Results: In accordance with the inclusion criteria wasselected There were16RCTs studies of (NSS) versus RN for RCC included in thisMeta-analysis.A total of20972patients from16studies were included,of which NSSgroup4952and RN group16020. After7years of cancer specific mortality relative risk(RR) RR=0.88,95%CI [0.771.01], P=0.07; after5years of cancer specific mortalityrelative risk (RR) RR=1.07,95%CI [0.751.51], P=0.71; after3years of cancer specificmortality relative risk (RR) RR=0.88,95%CI [0.701.12], P=0.30; the postoperativerecurrence of tumor is the relative risk (RR) RR=1.03,95%CI [0.691.55], P=0.88;postoperative tumor metastasis comparison of relative risk (RR) RR=0.99,95%CI [0.771.27], P=0.92; the occurrence of postoperative bleeding is the relative risk (RR)RR=1.58,95%CI [1.032.42], P=0.04; There were statistical significance;the occurrence ofpostoperative renal failure cases compared to the relative risk (RR) RR=0.97,95%CI [0.681.41], P=0.89; the occurrence of postoperative mortality compared to the relative risk(RR)RR=0.92,95%CI [0.681.23], P=0.56; Conclusions： There is no significant differences between NSS and RN with regard to five year cancer related mortality.Tumor recurrenceand metastasis. NSS could maximally preserve the function of remaining nephron andreduce the risk for kidey function failure.Although RN is superior to prevent thecomplications,NSS is an effective and reliable treatment for localizcd renal celIcarcinoma.But because small sample size, and still more RCT confirmed.