| Objective:The study of Chinese and Western combined with the clinical efficacy and safety of the treatment of lupus nephritis, for the future development of clinically effective, the safety of Chinese and western medicine and provide evidence.Methods:Chinese medicine hospital in Hubei Province,60cases of lupus nephritis (LN) patients were randomized controlled study.60cases of lupus nephritis (LN) patients were randomly divided into treatment and control groups. Treatment group on the basis of western medicine, with reference to the "Traditional Chinese Drug Guidelines for clinical research (Trial)"(2002, Zheng Xiaoyu, editor), accompanied by traditional Chinese medicine diagnosis and treatment and control group were treated with western medicine, the study lasted three months, were observed patients with TCM syndrome, lupus nephritis activity SLEDAI index (before treatment and1,2, and3months after the first record). Relevant physical and chemical examination, including:hemoglobin, white blood cells, serum albumin, serum creatinine and24h urinary protein, anti ds-DNA antibodies, antinuclear antibodies, anti-Sm antibodies, immune function, complement C3, C4, and erythrocyte sedimentation rate, urine RBC (each measured before and after treatment), as well as the safety assessment of the treatment group. Results1. Treatment group (n=30),27female,3male, age16to55years old, average age34.41±11.01years of age, duration of10to120months, average duration of58.60±15.33months; control group of30cases,26were female,4male andpeople aged19to58years, the average age of35.95±9.32years of age, duration of13to132months average duration of60.55±23.24months. In clinical manifestations, disease duration, clinical manifestations of the number of cases constitute a syndrome type composition of the number of cases statistically significant difference (P>0.05) were comparable.2. Treatment group, complete remission in4cases (13.33%), the total efficiency of96.67%; the control group, complete remission cases (3.33%), the total efficiency of76.67%, the difference was statistically significant (P<0.05).3. The treatment group TCM syndromes integral and lupus activity scores than the control group, the difference system. The total significance (P<0.05);4. Clinical indicators, the treatment group of hemoglobin, white blood cells, albumin, complement C3, C4, increased24-hour urinary protein excretion, the ANA and IgG, erythrocyte sedimentation rate, urine red blood cells to reduce anti-ds-DNA antibodies, sm antibodies negative, and the difference before and after treatment were statistically significant (P<0.05), serum creatinine, the treatment than before treatment, but the difference was statistically significant (P>0.05), to consider before and after treatment of patients with serum creatinine were within normal rangetherefore unable to reflect the change. In the control group before and after treatment, serum creatinine, complement C3, of IgG after treatment than before treatment, although improved, but the difference was not statistically significant (P>0.05). Treatment group and control group after treatment of various clinical indicators in the treatment group, white blood cell levels above the normal range in14cases, the control group after treatment, white blood cell levels above the normal range in17cases, the difference was not statistically significant (P>0.05), consider the patients with the whole use of hormones affect the blood like after treatment, serum creatinine difference not statistically significant (P>0.05), the main consideration in patients with pre-treatment serum creatinine in the normal range, and therefore does not reflect the significant differences in after treatment, anti-ds-DNA antibody and anti-Sm antibody positive comparison, the difference was not statistically significant (P>0.05), consider the two clinical indicators of negative slow, but this observation only last March related. The rest of the clinical indicators were statistically significant (P<0.05). These results suggest that Chinese and Western medicine combined with the treatment of lupus nephritis with good effect, can effectively improve the clinical symptoms, improve various laboratory parameters, and significantly better than the WM control group.5. Security assessment, medication during the observation period of treatment group, biochemical indices and auxiliary examination does not appear obvious abnormalities, significant efficacy in patients with stable condition, compared with the control group, no significant difference in the adverse reaction is not obvious, suggesting that combining Chinese and Westernadopted by the safety assessment of the treatment group can be incorporated into clinical treatment options.Conclusion:Chinese and Western combined with good clinical efficacy in treating lupus nephritis, can significantly reduce the TCM syndrome score and LN activity index to improve the indicators of relevant physical and chemical examination, and low incidence of adverse reactions of Integrative Medicine in lupus nephritiscan be obtained more satisfactory results. |
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