WLK Capsule And Granule On Pharmacodynamics Comparative Study Summary

A comparative study of WLK capsule and granulespharmacodynamic clear its effectiveness, the role of strong or weak, with theoriginal formulations of drugs on the efficacy advantages and characteristics, todetermine whether the practical value and development prospects.Method: By water dip should stress sexual, and acetate burning typeexperimental research gastric force Kang capsule and particles agent on size ratgastric ulcer of effect, using ammonia to large rat chronic gastritis of effect,acetate to small rat twist body reaction of effect, on hot Board to small rat painreaction of effect, on xylene to small rat acute ear swelling of effect, on cottonballs to small rat granulation swollen of effect, And pyloric ligation gastric juicesecretion in rats and the effect of an experimental study on the inhibition ofHelicobacter pylori in vitro experimental study on gastric power capsules andgranules in resisting gastric mucosal lesion (ulcer), on experimental chronicgastritis, contain the value-added role of Helicobacter pylori andanti-inflammatory, analgesic, and many other chronic gastritis, gastric ulcer andcomparative study of pharmacological treatment.Results:1. WLK capsule3dose groups and WLK granule group, on mouse water-immersion restraint stress-induced gastric ulcers forming an inhibitoryeffect, reduces ulcer index to improve ulcer healing rates.2. WLK capsule3dose groups and WLK granule groups, inhibiting the formation of gastric ulcerof rats with acetic acid burns may reduce the ulcer area, improving ulcerhealing rates. WLK capsule3dose groups and WLK particle group underoptical microscope depth of gastric ulcer and inflammatory reaction levels arelower than the model of the control group, and pyloric glands compensatoryhypertrophy and ulcer repair, histopathological score values statisticalsignificant difference (p<0.01~0.05), WLK capsule and granule onhistopathology of acetic acid-induced ulcer healing in rats (p>0.05). WLKcapsule Group (30.66g pharmacognostic/kg) and WLK particle Group onhuman epithe-lial cells around the ulcer CXCL-8(IL-8), NF κ B-p65(F-6)expression (S-P method) model of epithelial cells positive area fraction is lessthan control group, statistical differences are significant (p<0.01), with gastriculcer around human epithe-lial cells by inhibiting CXCL-8(IL-8), NF κ B-p65(F-6) expression.3. WLK capsule and high dose groups and WLKgranule inlow-and high-dose groups, intragastric administration30days in a row, cansignificantly reduce the ammonia water induced by chronic gastritis of ratsgastric sinus and the degree of inflammation of the gastric mucosa, inhibition ofatrophy in the gastric mucosa lesion with distinct. Low WLK capsule, highdose and WLK granule in higher doses, intragastric administration30days in arow, you can significantly reduce ammonia AB/PAS staining of chronic gastritis gastric mucosa reaction caused by damage, with the protection of gastric mucusbarrier system. WLK capsule dose in low doses and WLK granule, gastricantrum of stomach in rats model of and the degree of inflammation of thegastric mucosa is less than control group trends, statistics not significantlydifferent (p>0.05). WLK capsule in the low dose group and WLK granule, dosegroup, AB/PAS of rat gastric mucosa: a staining reaction intensity and rangethan the model set of trends, but statistics not significantly different (p>0.05).4.WLK capsule in high dose group and WLK granule in high dose group onacetic acid twisting pain response inhibition in mice; WLK capsule three dosegroups and WLK granule high dose groups can increase heat pain threshold inmice, shows that gastric capsules and granules in the context of the amount ofreagents have analgesic effects.5. WLK capsule3dose groups and WLKgranule3dose groups of p-xylene in mice ear swelling and inhibitory effect ofcotton ball Granuloma in mice have a certain tendency, but the statisticaldifferences are not significant (p>0.05).6. Wei kang capsule three dose groupsand group of WLK granule in rats with inhibit pyloric ligation total volume,total acidity of gastric juice and acid excretion excretion, and protease, andhave a certain dose-effect relationship between the trend; an elevated role ingastric juice pH and pepsin activity trends have increased, no significantdose-effect relations.7. WLK capsule on the experimental standard strains ofHelicobacter pylori clinical isolates of NCTC116371and NM-4, NM-9,XZ-267, SW-7, XZ-374, good bacteriostatic and bactericidal action, its MIC and MBC when the solution concentration of104cfu/ml/ml0.1g contents.Conclusion:WLK capsule and particles in the context of the amount ofreagents have basically the same resistance of gastric mucosal injury (ulcer), onexperimental chronic gastritis, and analgesic, anti-inflammatory, and otherbenefits of pharmacological treatment of gastric ulcer, chronic gastritis. It maybe through some mechanism of protection, inhibiting gastric acid secretion andgastric mucosa barrier of Helicobacter pylori achieved.