| 1.Objective1.1Design Hyperuricemia syndromes in traditional Chinese Medicine questionnaire and optimize the questionnaire so that the questionnaire could be developed practical and effective1.2Preliminary explore the syndrome factor and character of traditional Chinese Medicine in patient with hyperuricemia to provide the evidence of traditional Chinese medicine intervention2.Methods2.1Questionnaire designWe design Hyperuricemia syndromes in traditional Chinese Medicine questionnaire based on extensive literature research expert advice, guided by Chinese medicine theory, and apply the scale research methods.2.2Statistical analysis methods2.2.1Questionnaire reliability and validity analysisUsing Cronbach alpha coefficients and Guttman binary coefficient method to assess questionnaire, the construct validity in the field of TCM symptoms are used by factor analvsis.2.2.2Questionnaire entries optimization methodFilter entries from the sensitivity point of view using the degree of dispersion trend. Filter entries from independent and representative perspective using factor analysis. Filter entries from internal consistency using ronbach coefficient.2.2.3HUA TCM syndrome factor analysis methodWe explore the hidden variables of traditional Chinese medicine syndrome factors which in the internal and not visible, using the latent tree model method and through the significant variables of symptoms, setup hidden tree structure between hidden variables of Chinese medicine svndrome factors and analvze basic traditional Chinese medicine svndrome factors of the HUA and the relations between them.3Results3.1Questionnaire reliability and validity assessment3.1.1Questionnaire reliability evaluation According to the analysis in field of the questionnaire of TCM symptoms, the Cronbach coefficient a values of spleen, heart, kidney, liver, wet, phlegm, heat, deficiency of qi, deficiency of yin were0.725.0.707,0.656,0.670,0.726,0.550.0.514.0.656and0.612.the Cronbach coefficient alpha value of he whole area is0.891. The Nine dimensions Guttman split-half reliability values in the field of TCM symptoms are respectively0.656,0.766,0.669.0.592,0.621,0.543,0.489,0.559and0.580. The Guttman split-half reliability values in the entire field value is0.801.3.1.2Validity evaluationExplore the method of factor analysis and principal component analysis. Perform Equamax, iterative25times. This analysis extracted10the value of the characteristic roots greater than one common factor, the cumulative variance contribution rate of53.775%, and the value of each entry in the load on one common factor>0.4, the lower value of the load of the other common factor.3.2HUA risk factors screeningOverweight or obesity, alcohol consumption is the major risk factors of the HUA. the incidence of male is higher to female, the incidence rates of postmenopausal women is higher than premenopausal too. so the sex and age are also major risk factor for HUA3.3HUA Chinese medicine symptoms3.3.1Differences among Different ages of the HUA TCM symptomVariance equality test and two independent samples t test results showed that:Variance distribution of spontaneous, mouth sticky, smelly stool foul, sighing, mouth pain, dry mouth, cold limbs, dizziness, head weight, such as wrap, blurred vision, dry eyes, loose teeth, thirsty and do not want to drink, dull pale mouth, tinnitus, hearing loss, shortness of breath, agitation, amnesia, Xiong Xie fullness, legs, legs heavy, dry stool, nocturia and other symptoms in the two populations is different(P<0.05)The rate of people less than45years old who has "spontaneous, sighing, stool smell foul" is larger than people older than45(P<0.05)..The symptoms of which the rate in the people less than45is higher than older than45are limbs cold, dizziness, heavy head, such as wrap, blurred vision, dry eyes, loose teeth, mouth pain, dry mouth, thirst do not want to drink.sticky mouth, dull pale mouth, tinnitus, hearing loss, shortness of breath, agitation, amnesia, Xiong Xie fullness, legs, legs heavy, dry stool, nocturia (P<0.05), indicating that distribution of these symptoms the HUA in different age groups is different3.3.2The differences of TCM symptoms between HUA with or without dyslipidemiaVariance equality test and two independent samples t test results showed that the frequency of symptoms such as heat intolerance, mouth sticky, spontaneous, emotional in HUA plus dyslipidemia group were higher15%than the dyslipidemia group significantly (P<0.05).Compared with dyslipidemia. it shows that the hot and humid, the deficiency of the performance in the HUA plus dyslipidemia is more obvious than dyslipidemia.3.4Syndrome factor analysis for HUA Implicit tree modelUtilize heuristic single hill-climbing algorithm learning to get the implicit tree model with highest BIC score, the BIC score of-15671. the hidden variables demonstrated by the variable symptoms in the Implicit tree model was common TCM syndrome factors such as kidney deficiency, spleen deficiency, liver deficiency, damp heat, yin deficiency, qi stagnation and blood stasis. The syndrome factor of disease location mainly are liver, spleen, kidney. The syndrome factor of disease resistance mainly are deficiency and dampness. Qi stagnation and blood stasis are supplemented. It is consistent with judgment made by clinicians to patients.3.5HUA TCM syndromes Characteristics(1) Adopt Principal Components, perform an Equamax,iterative25times. By orthogonal rotation factor matrix, each entry of the symptoms in the basic common factor load values is greater than0.4. while the load value of the other common factor. Lower. Comprehensive analysis of factors contained in the entry, factor1reflects the symptoms of spleen deficiency, and factor2reflects the symptoms of liver and kidney deficiency, factor3reflects the symptoms of Spleen wet Yun, factor4reflects the symptoms of the liver is not comfortable. Factor5reflects symptoms of the phlegm internal resistance, factor6reflects the symptoms of qi and Yin deficiency, the factor7to reflect the symptoms of qi stagnation, the factors8reflect the symptoms of the spleen yang deficiency, factor9reflects the symptoms of liver yin deficiency, factor10reflects the symptoms of heat. (2) Hierarchical clustering to32Tongue and pulse variable, a limited cluster of classes3to8, from the proceeds of six kinds of classification results, gather information for the three types of signs, good dispersion, carddesignate the type of distribution is clearer, more in line with clinical practice, based on expert opinion, these three types of syndromes are named as follows:Damp-heat, spleen deficiency syndrome, stasis Syndrome.4Conclusion4.1Overweight or obese, drinking, gender, age is the main risk factors of the HUA4.2The main Chinese medicine symptoms of HUA are spontaneous perspiration and heat intolerance. TCM symptoms may have drowsiness, fatigue, agitation, amnesia, yellow urine, dry mouth, backache, hair loss, legs Shen, mouth pain, cold, dull pale mouth, nocturia. dry eyes. legs, raw stuffiness, blurred vision, insomnia, profuse sweating, dysphoria fever, tinnitus, dizziness, loose stool, head weight, such as wrap, hearing loss, shortness of breath, upset, disturbed, loose teeth, limbs cold, stool viscosity unhappy, sighing, stick mouth, bloating, muscle aches, chest tightness, joint pain, or thirsty and do not want to drink. The distribution of TCM symptoms among different age groups is different. The performance level of hot and humid and Qi deficiency in HUA population is more obvious than dyslipidemia population... |
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