The Difference Comrison Of The Different TCM Pasyndrome Types Of Diabetic Nephropathy Ⅲ~Ⅳ Period In Atrery IMT

Objective：This topic through the observation of the difference comparison of the different TCMsyndrome types of Diabetic nephropathy Ⅲ～Ⅳperiod in artery IMT, and the relationbetween Urinary albumin with artery IMT of DN patients, probe into the correlation of thedifferent Traditional Chinese Medicine syndrome types of DN Ⅲ～Ⅳperiod patients andAtherosclerosis. It provides ideas for the Traditional Chinese Medicine researching forclinical treatment of DN.Methods：According to WHO diagnostic criteria and Chinese Medicine of standards,60cases ofDN patients selected for the study. Detailed history, symptom and signs, will be observedin patients with syndrome differentiation type, divided into Qi and Yin Deficiency type,yin and yang deficiency type, Phlegm and blood stasis type three groups,Pumping fasting blood investigate three groups of patients with Triglyceride (TG),Cholesterol (TC), Low-density lipoprotein (LDL), High-density lipoprotein (HDL),checking morning urine three groups of UALB, doing color Doppler ultrasoundexamination of carotid, measuring of carotid artery Intimae-media thickness (IMT), andchecking carotid artery plaque. Analysis the difference comparison of the different TCMsyndrome types of Diabetic nephropathy Ⅲ～Ⅳperiod in Carotidartery, TG,TC,LDL,HDL and UALB; and the relationship of UALB and carotid IMT ofDN patients, to further explore the relationship of carotid atherosclerosis and DN.Select our hospital16cases of healthy parson as control group, and check their UALB,TC, TG, LDL, HDL and neck Vascular ultrasound, comparison of that and DN patients. Result:1DN patients comparing with the healthy control group: TG, TC, LDL,UALB,IMTand plaque detection rate increase significantly(P<O.O1)， HDL decrease (P<0.01).2The three DN groups of blood lipids with contrast: From TG, TC, LDL statisticalresults: Phlegm and blood stasis type was significantly higher than Qi and Yin Deficiencytype (P<0.01).Phlegm and blood stasis type was significantly higher than Yin and YangDeficiency type (P<0.01). From HDL statistical results: Qi and Yin Deficiency type, Yinand Yang Deficiency type and Phlegm and blood stasis type were no significant difference(P>0.05).3The three DN groups of IMT, checking rate of carotid artery plaque with contrast:From the results of statistical tests, Phlegm and blood stasis type was significantly higherthan Qi and Yin Deficiency type (P<0.01).Phlegm and blood stasis type was higher thanYin and Yang Deficiency type (P<0.01).4The three DN groups of UALB with contrast: From the results of statistical tests,Phlegm and blood stasis type was significantly higher than Qi and Yin Deficiency type(P<0.01).Phlegm and blood stasis type was higher than Yin and Yang Deficiency type(P<0.05).5The correlation of IMT and UALB: The scatter plot chart of IMT and UALB have alinear tread, r=0.481, P<0.01,indicating that the UALB and carotid artery IMT of Diabeticnephropathy is in a positive correlation, but less relevance.6The three DN groups of disease course with contrast: From the results of statisticaltests, Phlegm and blood stasis type was significantly higher than Qi and Yin Deficiencytype (P<0.01).Phlegm and blood stasis type was higher than Yin and Yang Deficiency type(P<0.05).Conclusion:1The Carotid artery IMT of the different TCM syndrome types of Diabeticnephropathy Ⅲ～Ⅳperiod was difference.Phlegm and blood stasis in patients with carotidIMT thickness was significantly higher than the other type. Phlegm and blood stasis inpatients was significantly higher than the other type with checking rate of carotid arteryplaque.2The UALB of the different TCM syndrome types of Diabetic nephropathy Ⅲ～Ⅳperiod was difference. Phlegm and blood stasis type in patients with UALB wassignificantly higher than the other types. It explains that Phlegm and blood stasis type was more serious than the other types and Phlegm and blood stasis type of DN to the end-stageDN was faster than the other types.3The blood lipids of the different TCM syndrome types of Diabetic nephropathyⅢ～Ⅳ period was difference. Phlegm and blood stasis type was significantly higher thanthe other types in TC, TG and LDL. This suggests that good blood lipids may reduce theformation of atherosclerotic plaque, slowing the process of DM to DN, reduce urinaryalbumin, and improve the quality of late life of diabetic patients.4UALB and carotid artery IMT of Diabetic nephropathy is in a positive correlation.This suggests that the process of DM producing urinary protein to DN were may closelyrelated to renal vascular atherosclerosis, which also has contributed greatly to theprobability of clinical predicting the development of DM to DN based on carotid IMT.